HIST2H2BF

Histon H2B tip 2-F jest protein koji je kod ljudi kodiran genom HIST2H2BF sa hromosoma 1.

HIST2H2BF
Identifikatori
Aliasi	H2BC18
Vanjski ID-jevi	MGI: 2448413 HomoloGene: 136264 GeneCards: H2BC18
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q21.2 Početak 149,782,689 bp Kraj 149,812,373 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3|3 F2.1 Početak 96,177,068 bp Kraj 96,177,448 bp
Ontologija gena Molekularna funkcija • protein heterodimerization activity • vezivanje sa DNK • molekularna funkcija Ćelijska komponenta • hromosom • Nukleosom • Egzosom • jedro • nukleoplazma • citosol Biološki proces • nucleosome assembly Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	440689	319189
Ensembl	ENSG00000203814	ENSMUSG00000105827
UniProt	Q5QNW6	Q64525
RefSeq (mRNK)	NM_001024599 NM_001161334	NM_175666
RefSeq (bjelančevina)	NP_001019770 NP_001154806	NP_783597
Lokacija (UCSC)	Chr 1: 149.78 – 149.81 Mb	Chr 3: 96.18 – 96.18 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 126 aminokiselina, a molekulska težina 13.920 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MPDPAKSAPA		PKKGSKKAVT		KVQKKDGKKR		KRSRKESYSV		YVYKVLKQVH
PDTGISSKAM		GIMNSFVNDI		FERIAGEASR		LAHYNKRSTI		TSREIQTAVR
LLLPGELAKH		AVSEGTKAVT		KYTSSK

Dopunska literatura

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cheung WL, Ajiro K, Samejima K, et al. (2003). "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase". Cell. 113 (4): 507–17. doi:10.1016/S0092-8674(03)00355-6. PMID 12757711. S2CID 21854.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Golebiowski F, Kasprzak KS (2007). "Inhibition of core histones acetylation by carcinogenic nickel(II)". Mol. Cell. Biochem. 279 (1–2): 133–9. doi:10.1007/s11010-005-8285-1. PMID 16283522. S2CID 25071586.
• Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation". Mol. Cell. 20 (4): 601–11. doi:10.1016/j.molcel.2005.09.025. PMID 16307923.
• Bonenfant D, Coulot M, Towbin H, et al. (2006). "Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry". Mol. Cell. Proteomics. 5 (3): 541–52. doi:10.1074/mcp.M500288-MCP200. PMID 16319397.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Pavri R, Zhu B, Li G, et al. (2006). "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II". Cell. 125 (4): 703–17. doi:10.1016/j.cell.2006.04.029. PMID 16713563. S2CID 2614680.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.