HES3

Transkripcijski faktor 3 Hes porodice bHLH jest protein koji je kod ljudi kodiran genom HES3 sa hromosoma 1.

HES3
Identifikatori
Aliasi	HES3
Vanjski ID-jevi	OMIM: 609971 MGI: 104877 HomoloGene: 7358 GeneCards: HES3
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1p36.31 Početak 6,244,179 bp Kraj 6,245,578 bp
Lokacija gena (miš) Hrom. Hromosom 4 (miš) Bend 4 E2|4 83.01 cM Početak 152,370,429 bp Kraj 152,376,119 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • transcription factor binding • protein dimerization activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding Ćelijska komponenta • jedro Biološki proces • hindbrain morphogenesis • trochlear nerve development • midbrain-hindbrain boundary morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0009373 regulation of transcription, DNA-templated • regulation of timing of neuron differentiation • regulation of neurogenesis • oculomotor nerve development • transcription, DNA-templated • midbrain development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • neural tube development • somitogenesis • Notch signaling pathway • Ćelijska diferencijacija • anterior/posterior pattern specification Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	390992	15207
Ensembl	ENSG00000173673	ENSMUSG00000028946
UniProt	Q5TGS1	Q61657
RefSeq (mRNK)	NM_001024598	NM_008237
RefSeq (bjelančevina)	NP_001019769	NP_032263 NP_001390720 NP_001390721 NP_001390722 NP_001390723
Lokacija (UCSC)	Chr 1: 6.24 – 6.25 Mb	Chr 4: 152.37 – 152.38 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 186 aminokiselina, a molekulska težina 19.968 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEKKRRARIN		VSLEQLKSLL		EKHYSHQIRK		RKLEKADILE		LSVKYMRSLQ
NSLQGLWPVP		RGAEQPSGFR		SCLPGVSQLL		RRGDEVGSGL		RCPLVPESAA
GSTMDSAGLG		QEAPALFRPC		TPAVWAPAPA		AGGPRSPPPL		LLLPESLPGS
SASVPPPQPA		SSRCAESPGL		GLRVWRPWGS		PGDDLN

Dopunska literatura

• Katoh M, Katoh M (august 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Katoh M, Katoh M (august 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.
• Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Laporte J, Kitagawa M, Ogata T (februar 2008). "Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence". The Journal of Biological Chemistry. 283 (9): 5525–32. doi:10.1074/jbc.M703289200. PMID 18162467.
• Park DM, Jung J, Masjkur J, Makrogkikas S, Ebermann D, Saha S, Rogliano R, Paolillo N, Pacioni S, McKay RD, Poser S, Androutsellis-Theotokis A (2013). "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics". Scientific Reports. 3: 1095. Bibcode:2013NatSR...3E1095P. doi:10.1038/srep01095. PMC 3566603. PMID 23393614.