GUF1

GUF1 GTPazni homolog jest protein koji je kod ljudi kodiran genom GUF1 sa hromosoma 4. To je mitohondrijski homolog elongacijskog faktora 4.

GUF1
Identifikatori
Aliasi	GUF1
Vanjski ID-jevi	OMIM: 617064 MGI: 2140726 HomoloGene: 6505 GeneCards: GUF1
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek) Bend 4p12 Početak 44,678,420 bp Kraj 44,700,928 bp
Lokacija gena (miš) Hrom. Hromosom 5 (miš) Bend 5|5 C3.1 Početak 69,714,266 bp Kraj 69,733,316 bp
Ontologija gena Molekularna funkcija • nucleotide binding • GTP binding • hydrolase activity • GO:0006184 GTPase activity • ribosome binding Ćelijska komponenta • mitochondrial inner membrane • membrana • mitohondrija • mitochondrial matrix Biološki proces • Biosinteza bjelančevina • positive regulation of translation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	60558	231279
Ensembl	ENSG00000151806	ENSMUSG00000029208
UniProt	Q8N442	Q8C3X4
RefSeq (mRNK)	NM_021927 NM_001345867 NM_001345868 NM_001345869	NM_172711 NM_182768 NM_001310631
RefSeq (bjelančevina)	NP_001332796 NP_001332797 NP_001332798 NP_068746	NP_001297560 NP_766299
Lokacija (UCSC)	Chr 4: 44.68 – 44.7 Mb	Chr 5: 69.71 – 69.73 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 669 aminokiselina, а molekulska težina 74.328 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MWTLVGRGWG		CARALAPRAT		GAALLVAPGP		RSAPTLGAAP		ESWATDRLYS
SAEFKEKLDM		SRFPVENIRN		FSIVAHVDHG		KSTLADRLLE		LTGTIDKTKN
NKQVLDKLQV		ERERGITVKA		QTASLFYNCE		GKQYLLNLID		TPGHVDFSYE
VSRSLSACQG		VLLVVDANEG		IQAQTVANFF		LAFEAQLSVI		PVINKIDLKN
ADPERVENQI		EKVFDIPSDE		CIKISAKLGT		NVESVLQAII		ERIPPPKVHR
KNPLRALVFD		STFDQYRGVI		ANVALFDGVV		SKGDKIVSAH		TQKTYEVNEV
GVLNPNEQPT		HKLYAGQVGY		LIAGMKDVTE		AQIGDTLCLH		KQPVEPLPGF
KSAKPMVFAG		MYPLDQSEYN		NLKSAIEKLT		LNDSSVTVHR		DSSLALGAGW
RLGFLGLLHM		EVFNQRLEQE		YNASVILTTP		TVPYKAVLSS		SKLIKEHREK
EITIINPAQF		PDKSKVTEYL		EPVVLGTIIT		PDEYTGKIMM		LCEARRAVQK
NMIFIDQNRV		MLKYLFPLNE		IVVDFYDSLK		SLSSGYASFD		YEDAGYQTAE
LVKMDILLNG		NTVEELVTVV		HKDKAHSIGK		AICERLKDSL		PRQLFEIAIQ
AAIGSKIIAR		ETVKAYRKNV		LAKCYGGDIT		RKMKLLKRQA		EGKKKLRKIG
NVEVPKDAFI		KVLKTQSSK

Dopunska literatura

• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.