GTPBP1
GTP–vezujući protein 1 jest protein koji je kod ljudi kodiran genom GTPBP1 sa hromosoma 22.[5][6]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 669 aminokiselina, a molekulska težina 72.454 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MATERSRSAM | DSPVPASMFA | PEPSSPGAAR | AAAAAARLHG | GFDSDCSEDG | ||||
| EALNGEPELD | LTSKLVLVSP | TSEQYDSLLR | QMWERMDEGC | GETIYVIGQG | ||||
| SDGTEYGLSE | ADMEASYATV | KSMAEQIEAD | VILLRERQEA | GGRVRDYLVR | ||||
| KRVGDNDFLE | VRVAVVGNVD | AGKSTLLGVL | THGELDNGRG | FARQKLFRHK | ||||
| HEIESGRTSS | VGNDILGFDS | EGNVVNKPDS | HGGSLEWTKI | CEKSTKVITF | ||||
| IDLAGHEKYL | KTTVFGMTGH | LPDFCMLMVG | SNAGIVGMTK | EHLGLALALN | ||||
| VPVFVVVTKI | DMCPANILQE | TLKLLQRLLK | SPGCRKIPVL | VQSKDDVIVT | ||||
| ASNFSSERMC | PIFQISNVTG | ENLDLLKMFL | NLLSPRTSYR | EEEPAEFQID | ||||
| DTYSVPGVGT | VVSGTTLRGL | IKLNDTLLLG | PDPLGNFLSI | AVKSIHRKRM | ||||
| PVKEVRGGQT | ASFALKKIKR | SSIRKGMVMV | SPRLNPQASW | EFEAEILVLH | ||||
| HPTTISPRYQ | AMVHCGSIRQ | TATILSMDKD | CLRTGDKATV | HFRFIKTPEY | ||||
| LHIDQRLVFR | EGRTKAVGTI | TKLLQTTNNS | PMNSKPQQIK | MQSTKKGPLT | ||||
| KRDEGGPSGG | PAVGAPPPGD | EASSVGAGQP | AASSNLQPQP | KPSSGGRRRG | ||||
| GQRHKVKSQG | ACVTPASGC |
Funkcija uredi
Ovaj gen je pojačano reguliran interferonom-gama i kodira protein koji je član porodice AGP11/GTPBP1, GTP-vezujućih proteina. Strukturno sličan protein je pronađen kod miševa, gdje poremećaj gena za taj protein nije bio vidljiv fenotip.[6]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100226 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042535 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.
- ^ a b c "Entrez Gene: GTPBP1 GTP binding protein 1".
Dopunska literatura uredi
- Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein". Biochem. J. 336 (2): 381–6. doi:10.1042/bj3360381. PMC 1219882. PMID 9820815.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
- Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID 10833435.
- Senju S, Iyama K, Kudo H, et al. (2000). "Immunocytochemical analyses and targeted gene disruption of GTPBP1". Mol. Cell. Biol. 20 (17): 6195–200. doi:10.1128/MCB.20.17.6195-6200.2000. PMC 86094. PMID 10938096.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.