GTPBP1

GTPBP1
Identifikatori
Aliasi	GTPBP1
Vanjski ID-jevi	OMIM: 602245 MGI: 109443 HomoloGene: 3165 GeneCards: GTPBP1
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	38,738,299 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	79,605,680 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GTP binding; • vezivanje sa RNK; • GO:0006184 GTPase activity; • translation elongation factor activity;
Ćelijska komponenta	• citoplazma; • cytoplasmic exosome (RNase complex); • citosol; • membrana;
Biološki proces	• positive regulation of mRNA catabolic process; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • GO:0072468 Transdukcija signala; • GTP metabolic process; • translational elongation;
	Izvori:Amigo / QuickGO
Ortolozi
	9567
	14904
	ENSG00000100226
	ENSMUSG00000042535
	O00178
	O08582
	NM_004286
	NM_013818
	NP_004277
	NP_038846
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

GTP–vezujući protein 1 jest protein koji je kod ljudi kodiran genom GTPBP1 sa hromosoma 22.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 669 aminokiselina, a molekulska težina 72.454 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MATERSRSAM	DSPVPASMFA	PEPSSPGAAR	AAAAAARLHG	GFDSDCSEDG
EALNGEPELD	LTSKLVLVSP	TSEQYDSLLR	QMWERMDEGC	GETIYVIGQG
SDGTEYGLSE	ADMEASYATV	KSMAEQIEAD	VILLRERQEA	GGRVRDYLVR
KRVGDNDFLE	VRVAVVGNVD	AGKSTLLGVL	THGELDNGRG	FARQKLFRHK
HEIESGRTSS	VGNDILGFDS	EGNVVNKPDS	HGGSLEWTKI	CEKSTKVITF
IDLAGHEKYL	KTTVFGMTGH	LPDFCMLMVG	SNAGIVGMTK	EHLGLALALN
VPVFVVVTKI	DMCPANILQE	TLKLLQRLLK	SPGCRKIPVL	VQSKDDVIVT
ASNFSSERMC	PIFQISNVTG	ENLDLLKMFL	NLLSPRTSYR	EEEPAEFQID
DTYSVPGVGT	VVSGTTLRGL	IKLNDTLLLG	PDPLGNFLSI	AVKSIHRKRM
PVKEVRGGQT	ASFALKKIKR	SSIRKGMVMV	SPRLNPQASW	EFEAEILVLH
HPTTISPRYQ	AMVHCGSIRQ	TATILSMDKD	CLRTGDKATV	HFRFIKTPEY
LHIDQRLVFR	EGRTKAVGTI	TKLLQTTNNS	PMNSKPQQIK	MQSTKKGPLT
KRDEGGPSGG	PAVGAPPPGD	EASSVGAGQP	AASSNLQPQP	KPSSGGRRRG
GQRHKVKSQG	ACVTPASGC

Funkcija

Ovaj gen je pojačano reguliran interferonom-gama i kodira protein koji je član porodice AGP11/GTPBP1, GTP-vezujućih proteina. Strukturno sličan protein je pronađen kod miševa, gdje poremećaj gena za taj protein nije bio vidljiv fenotip.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100226 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042535 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.
^ ^a ^b ^c "Entrez Gene: GTPBP1 GTP binding protein 1".

Dopunska literatura

Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein". Biochem. J. 336 (2): 381–6. doi:10.1042/bj3360381. PMC 1219882. PMID 9820815.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID 10833435.
Senju S, Iyama K, Kudo H, et al. (2000). "Immunocytochemical analyses and targeted gene disruption of GTPBP1". Mol. Cell. Biol. 20 (17): 6195–200. doi:10.1128/MCB.20.17.6195-6200.2000. PMC 86094. PMID 10938096.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100226 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042535 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9070279-5] Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.

[entrez-6] "Entrez Gene: GTPBP1 GTP binding protein 1".

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