GPIHBP1

GPIHBP1
Identifikatori
Aliasi	GPIHBP1
Vanjski ID-jevi	OMIM: 612757 HomoloGene: 18651 GeneCards: GPIHBP1
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	143,217,170 bp
Ontologija gena
Molekularna funkcija	• lipid binding; • protein transmembrane transporter activity; • lipase binding; • chylomicron binding; • lipoprotein particle binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• membrana; • intracellular anatomical structure; • basolateral plasma membrane; • apical plasma membrane; • anchored component of external side of plasma membrane; • high-density lipoprotein particle; • anchored component of membrane; • extracellular region; • ćelijska membrana; • external side of plasma membrane;
Biološki proces	• protein transmembrane transport; • response to heparin; • regulation of lipoprotein lipase activity; • intracellular protein transport; • protein import; • protein localization to cell surface; • cholesterol homeostasis; • transcytosis; • protein stabilization; • positive regulation of lipoprotein lipase activity; • triglyceride homeostasis; • positive regulation of chylomicron remnant clearance; • retinoid metabolic process; • chylomicron remodeling;
	Izvori:Amigo / QuickGO
Ortolozi
	338328
	n/a
	ENSG00000277494
	n/a
	Q8IV16
	n/a
	NM_178172; NM_001301772
	n/a
	NP_001288701; NP_835466
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Glikozilfosfatidilinozitol-usidreni protein 1 (GPI-HBP1) koji veže lipoprotein velike gustoće (GPI-HBP1), također poznat i kao protein-vezujući lipoprotein visoke gustoće 1 je protein koji kod ljudi kodiran genom GPIHBP1.^[3]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 184 aminokiseline, а molekulska težina 19.806 Da.^[4]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKALGAVLLA	LLLCGRPGRG	QTQQEEEEED	EDHGPDDYDE	EDEDEVEEEE
TNRLPGGRSR	VLLRCYTCKS	LPRDERCNLT	QNCSHGQTCT	TLIAHGNTES
GLLTTHSTWC	TDSCQPITKT	VEGTQVTMTC	CQSSLCNVPP	WQSSRVQDPT
GKGAGGPRGS	SETVGAALLL	NLLAGLGAMG	ARRP

Funkcija uredi

Hranjive masti se crijevima pakiraju u trigliceridima bogate lipoproteina zvane hilomikroni. Trigliceridi u hilomikronima se hidroliziraju lipoprotein-lipazom (LPL) duž lumenake površine kapilara, uglavnom u srcu, skeletnim mišićima i masnom tkivu. GPIHBP1 je protein kapilarnih endotelnih ćelija koji pruža platformu za LPL-posredovanu obradu hilomikrona.^[3]^[5]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000277494 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1".
^ "UniProt, Q8IV16" (jezik: engleski). Pristupljeno 18. 9. 2021.
^ Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG (april 2007). "Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons". Cell Metab. 5 (4): 279–91. doi:10.1016/j.cmet.2007.02.002. PMC 1913910. PMID 17403372.

Dopunska literatura uredi

Coca-Prieto, I.; Kroupa, O.; Gonzalez-Santos, P.; Magne, J.; Olivecrona, G.; Ehrenborg, E.; Valdivielso, P. (2011). "Childhood-onset chylomicronaemia with reduced plasma lipoprotein lipase activity and mass: Identification of a novelGPIHBP1mutation". Journal of Internal Medicine. 270 (3): 224–228. doi:10.1111/j.1365-2796.2011.02361.x. PMID 21314738. S2CID 10833906.
Olivecrona, G.; Ehrenborg, E.; Semb, H.; Makoveichuk, E.; Lindberg, A.; Hayden, M. R.; Gin, P.; Davies, B. S. J.; Weinstein, M. M.; Fong, L. G.; Beigneux, A. P.; Young, S. G.; Olivecrona, T.; Hernell, O. (2009). "Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia". The Journal of Lipid Research. 51 (6): 1535–1545. doi:10.1194/jlr.M002717. PMC 3035517. PMID 20026666.
Charriere, S.; Peretti, N.; Bernard, S.; Di Filippo, M.; Sassolas, A.; Merlin, M.; Delay, M.; Debard, C.; Lefai, E.; Lachaux, A.; Moulin, P.; Marcais, C. (2011). "GPIHBP1 C89F Neomutation and Hydrophobic C-Terminal Domain G175R Mutation in Two Pedigrees with Severe Hyperchylomicronemia". Journal of Clinical Endocrinology & Metabolism. 96 (10): E1675–E1679. doi:10.1210/jc.2011-1444. PMID 21816778.
Gin, P.; Yin, L.; Davies, B. S. J.; Weinstein, M. M.; Ryan, R. O.; Bensadoun, A.; Fong, L. G.; Young, S. G.; Beigneux, A. P. (2008). "The Acidic Domain of GPIHBP1 is Important for the Binding of Lipoprotein Lipase and Chylomicrons". Journal of Biological Chemistry. 283 (43): 29554–29562. doi:10.1074/jbc.M802579200. PMC 2662032. PMID 18713736.
Young, S. G.; Davies, B. S. J.; Voss, C. V.; Gin, P.; Weinstein, M. M.; Tontonoz, P.; Reue, K.; Bensadoun, A.; Fong, L. G.; Beigneux, A. P. (2011). "GPIHBP1, an endothelial cell transporter for lipoprotein lipase". The Journal of Lipid Research. 52 (11): 1869–1884. doi:10.1194/jlr.R018689. PMC 3196223. PMID 21844202.
Beigneux, A. P.; Franssen, R.; Bensadoun, A.; Gin, P.; Melford, K.; Peter, J.; Walzem, R. L.; Weinstein, M. M.; Davies, B. S. J.; Kuivenhoven, J. A.; Kastelein, J. J. P.; Fong, L. G.; Dallinga-Thie, G. M.; Young, S. G. (2009). "Chylomicronemia with a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase". Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (6): 956–962. doi:10.1161/ATVBAHA.109.186577. PMC 2811263. PMID 19304573.
Sonnenburg, W. K.; Yu, D.; Lee, E. C.; Xiong, W.; Gololobov, G.; Key, B.; Gay, J.; Wilganowski, N.; Hu, Y.; Zhao, S.; Schneider, M.; Ding, Z. -M.; Zambrowicz, B. P.; Landes, G.; Powell, D. R.; Desai, U. (2009). "GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4". The Journal of Lipid Research. 50 (12): 2421–2429. doi:10.1194/jlr.M900145-JLR200. PMC 2781314. PMID 19542565.
Young, S. G.; Davies, B. S.; Fong, L. G.; Gin, P.; Weinstein, M. M.; Bensadoun, A. ?; Beigneux, A. P. (2007). "GPIHBP1: An endothelial cell molecule important for the lipolytic processing of chylomicrons". Current Opinion in Lipidology. 18 (4): 389–396. doi:10.1097/MOL.0b013e3281527914. PMC 2888298. PMID 17620854.
Ruge, T.; Sukonina, V.; Kroupa, O.; Makoveichuk, E.; Lundgren, M.; Svensson, M. K.; Olivecrona, G.; Eriksson, J. W. (2012). "Effects of hyperinsulinemia on lipoprotein lipase, angiopoietin-like protein 4, and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in subjects with and without type 2 diabetes mellitus". Metabolism. 61 (5): 652–660. doi:10.1016/j.metabol.2011.09.014. PMID 22078753.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000277494 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1".

[UniProt-4] "UniProt, Q8IV16" (jezik: engleski). Pristupljeno 18. 9. 2021.

[pmid17403372-5] Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG (april 2007). "Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons". Cell Metab. 5 (4): 279–91. doi:10.1016/j.cmet.2007.02.002. PMC 1913910. PMID 17403372.

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