GON4L

GON-4-liki protein jest protein koji je kod ljudi kodiran genom GON4L sa hromosoma 1. To je jedarni protein koji sadrži dva serinskog fosfozita i poprečnu vezu lizin–glutamin i smatra se da je transkripcijski faktor.

GON4L
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1UG2
Identifikatori
Aliasi	GON4L
Vanjski ID-jevi	OMIM: 610393 MGI: 1917579 HomoloGene: 13002 GeneCards: GON4L
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q22 Početak 155,749,659 bp Kraj 155,859,400 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3|3 F1 Početak 88,835,231 bp Kraj 88,910,103 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • GO:0001106 transcription corepressor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • nukleoplazma • nuclear body • jedro Biološki proces • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • B cell differentiation • GO:0045996 negative regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	54856	76022
Ensembl	ENSG00000116580	ENSMUSG00000054199
UniProt	Q3T8J9	Q9DB00
RefSeq (mRNK)	NM_001037533 NM_001282856 NM_001282858 NM_001282860 NM_001282861 NM_032292 NM_025174	NM_001242372 NM_027389
RefSeq (bjelančevina)	NP_001269785 NP_001269787 NP_001269789 NP_001269790 NP_115668	NP_001229301 NP_081665
Lokacija (UCSC)	Chr 1: 155.75 – 155.86 Mb	Chr 3: 88.84 – 88.91 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 2.241 aminokiselina, a molekulska težina 248.620 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MLPCKKRRTT		VTESLQHKGN		QEENNVDLES		AVKPESDQVK		DLSSVSLSWD
PSHGRVAGFE		VQSLQDAGNQ		LGMEDTSLSS		GMLTQNTNVP		ILEGVDVAIS
QGITLPSLES		FHPLNIHIGK		GKLHATGSKR		GKKMTLRPGP		VTQEDRCDHL
TLKEPFSGEP		SEEVKEEGGK		PQMNSEGEIP		SLPSGSQSAK		PVSQPRKSTQ
PDVCASPQEK		PLRTLFHQPE		EEIEDGGLFI		PMEEQDNEES		EKRRKKKKGT
KRKRDGRGQE		GTLAYDLKLD		DMLDRTLEDG		AKQHNLTAVN		VRNILHEVIT
NEHVVAMMKA		AISETEDMPM		FEPKMTRSKL		KEVVEKGVVI		PTWNISPIKK
ANEIKPPQFV		DIHLEEDDSS		DEEYQPDDEE		EDETAEESLL		ESDVESTASS
PRGAKKSRLR		QSSEMTETDE		ESGILSEAEK		VTTPAIRHIS		AEVVPMGPPP
PPKPKQTRDS		TFMEKLHAVD		EELASSPVCM		DSFQPMDDSL		IAFRTRSKMP
LKDVPLGQLE		AELQAPDITP		DMYDPNTADD		EDWKMWLGGL		MNDDVGNEDE
ADDDDDPEYN		FLEDLDEPDT		EDFRTDRAVR		ITKKEVNELM		EELFETFQDE
MGFSNMEDDG		PEEEECVAEP		RPNFNTPQAL		RFEEPLANLL		NEQHRTVKEL
FEQLKMKKSS		AKQLQEVEKV		KPQSEKVHQT		LILDPAQRKR		LQQQMQQHVQ
LLTQIHLLAT		CNPNLNPEAT		TTRIFLKELG		TFAQSSIALH		HQYNPKFQTL
FQPCNLMGAM		QLIEDFSTHV		SIDCSPHKTV		KKTANEFPCL		PKQVAWILAT
SKVFMYPELL		PVCSLKAKNP		QDKIVFTKAE		DNLLALGLKH		FEGTEFPNPL
ISKYLLTCKT		AHQLTVRIKN		LNMNRAPDNI		IKFYKKTKQL		PVLGKCCEEI
QPHQWKPPIE		REEHRLPFWL		KASLPSIQEE		LRHMADGARE		VGNMTGTTEI
NSDRSLEKDN		LELGSESRYP		LLLPKGVVLK		LKPVATRFPR		KAWRQKRSSV
LKPLLIQPSP		SLQPSFNPGK		TPARSTHSEA		PPSKMVLRIP		HPIQPATVLQ
TVPGVPPLGV		SGGESFESPA		ALPAVPPEAR		TSFPLSESQT		LLSSAPVPKV
MLPSLAPSKF		RKPYVRRRPS		KRRGVKASPC		MKPAPVIHHP		ASVIFTVPAT
TVKIVSLGGG		CNMIQPVNAA		VAQSPQTIPI		TTLLVNPTSF		PCPLNQSLVA
SSVSPLIVSG		NSVNLPIPST		PEDKAHVNVD		IACAVADGEN		AFQGLEPKLE
PQELSPLSAT		VFPKVEHSPG		PPLADAECQE		GLSENSACRW		TVVKTEEGRQ
ALEPLPQGIQ		ESLNNPTPGD		LEEIVKMEPE		EAREEISGSP		ERDICDDIKV
EHAVELDTGA		PSEELSSAGE		VTKQTVLQKE		EERSQPTKTP		SSSQEPPDEG
TSGTDVNKGS		SKNALSSMDP		EVRLSSPPGK		PEDSSSVDGQ		SVGTPVGPET
GGEKNGPEEE		EEEDFDDLTQ		DEEDEMSSAS		EESVLSVPEL		QETMEKLTWL
ASERRMSQEG		ESEEENSQEE		NSEPEEEEEE		EAEGMESLQK		EDEMTDEAVG
DSAEKPPTFA		SPETAPEVET		SRTPPGESIK		AAGKGRNNHR		ARNKRGSRAR
ASKDTSKLLL		LYDEDILERD		PLREQKDLAF		AQAYLTRVRE		ALQHIPGKYE
DFLQVIYEFE		SSTQRRTAVD		LYKSLQILLQ		DWPQLLKDFA		AFLLPEQALA
CGLFEEQQAF		EKSRKFLRQL		EICFAENPSH		HQKIIKVLQG		CADCLPQEIT
ELKTQMWQLL		KGHDHLQDEF		SIFFDHLRPA		ASRMGDFEEI		NWTEEKEYEF
DGFEEVALPD		VEEEEEPPKI		PTASKNKRKK		EIGVQNHDKE		TEWPDGAKDC
ACSCHEGGPD		SKLKKSKRRS		CSHCSSKVCD		SKSYKSKEPH		ELVGSSPHRE
ASPMPGAKEA		GQGKDMMEEE		APEERESTEA		TQSRTVRTTR		KGEMPVSAGL
AVGSTLPSPR		EVTVTERLLL		DGPPPHSPET		PQFPPTTGAV		LYTVKRNQVG
PEVRSCPKAS		PRLQKEREGQ		KAVSESEALM		LVWDASETEK		LPGTVEPPAS
FLSPVSSKTR		DAGRRHVSGK		PDTQERWLPS		SRARVKTRDR		TCPVHESPSG
IDTSETSPKA		PRGGLAKDSG		TQAKGPEGEQ		QPKAAEATVC		ANNSKVSSTG
EKVVLWTREA		DRVILTMCQE		QGAQPQTFNI		ISQQLGNKTP		AEVSHRFREL
MQLFHTACEA		SSEDEDDATS		TSNADQLSDH		GDLLSEEELD		E

Dopunska literatura

• Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (decembar 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (januar 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (oktobar 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, et al. (maj 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.