GMDS
GDP-manozna 4,6 dehidrataza jest enzim koji je kod ljudi kodiran genom GMDS.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 372 aminokiseline, а molekulska težina 41.950 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAHAPARCPS | ARGSGDGEMG | KPRNVALITG | ITGQDGSYLA | EFLLEKGYEV | ||||
| HGIVRRSSSF | NTGRIEHLYK | NPQAHIEGNM | KLHYGDLTDS | TCLVKIINEV | ||||
| KPTEIYNLGA | QSHVKISFDL | AEYTADVDGV | GTLRLLDAVK | TCGLINSVKF | ||||
| YQASTSELYG | KVQEIPQKET | TPFYPRSPYG | AAKLYAYWIV | VNFREAYNLF | ||||
| AVNGILFNHE | SPRRGANFVT | RKISRSVAKI | YLGQLECFSL | GNLDAKRDWG | ||||
| HAKDYVEAMW | LMLQNDEPED | FVIATGEVHS | VREFVEKSFL | HIGKTIVWEG | ||||
| KNENEVGRCK | ETGKVHVTVD | LKYYRPTEVD | FLQGDCTKAK | QKLNWKPRVA | ||||
| FDELVREMVH | ADVELMRTNP | NA |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000112699 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038372 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA (maj 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi:10.1074/jbc.273.14.8193. PMID 9525924.
- ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
- ^ "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".
- ^ "UniProt, O60547" (jezik: engleski). Pristupljeno 2. 10. 2021.
Dopunska literatura
uredi- Ohyama C, Smith PL, Angata K, et al. (1998). "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells". J. Biol. Chem. 273 (23): 14582–14587. doi:10.1074/jbc.273.23.14582. PMID 9603974.
- Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–3175. doi:10.1074/jbc.M107927200. PMID 11698403.
- Eshel R, Besser M, Zanin A, et al. (2002). "The FX enzyme is a functional component of lymphocyte activation". Cell. Immunol. 213 (2): 141–148. doi:10.1006/cimm.2001.1872. PMID 11831876.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.