Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 233 aminokiseline , а molekulska težina 24.051 Da .[8]
10 20 30 40 50 MPCRREEEEE AGEEAEGEEE EDDSFLLLQQ SVTLGSSGEV DRLVAQIGET LQLDAAQDSP ASPCAPPGVP LRAPGPLAAA VPADKARPPA VPLLLPPASA ETVGPAPSGA LRCALGDRGR VRGRAAPYCV AEVAAGPSAL PGPCRRGWLR DAVTSRRLQQ RRWTQAGARA GDDDPHRLLQ QLVLSGNLIK EAVRRLQRAV AAVAATGPAS APGPGGGRSG PDRIALQPSG SLL
^ a b c GRCh38: Ensembl release 89: ENSG00000181274 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047604 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis" . Cell . 93 (6): 1031–41. doi :10.1016/S0092-8674(00)81208-8 PMID 9635432 . S2CID 17951152 . ^ Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun . 281 (3): 815–20. doi :10.1006/bbrc.2001.4421 . PMID 11237732 . ^ a b "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2" .^ "UniProt, O75474" . Pristupljeno 2. 9. 2021 .
Dopunska literatura
uredi
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation" . Structure . 9 (12): 1143–52. doi :10.1016/S0969-2126(01)00679-7 PMID 11738041 . Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2". Gene . 291 (1–2): 17–27. doi :10.1016/S0378-1119(02)00594-2 . PMID 12095675 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81. Bibcode :2004Natur.429..375D . doi :10.1038/nature02462 PMID 15164054 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Stoothoff WH, Cho JH, McDonald RP, Johnson GV (2005). "FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation" . J. Biol. Chem . 280 (1): 270–6. doi :10.1074/jbc.M410061200 PMID 15522877 . 
