FBP1

Fruktoza-1,6-bisfosfataza 1 je proteinski enzim koji je kod ljudi kodiran genom FBP1.

FBP1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1FTA, 2FHY, 2FIE, 2FIX, 2JJK, 2VT5, 2WBB, 2WBD, 2Y5K, 2Y5L, 3A29, 3KBZ, 3KC0, 3KC1, 4MJO
Identifikatori
Aliasi	FBP1
Vanjski ID-jevi	OMIM: 611570 MGI: 95492 HomoloGene: 55467 GeneCards: FBP1
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek) Bend 9q22.32 Početak 94,603,133 bp Kraj 94,640,249 bp
Lokacija gena (miš) Hrom. Hromosom 13 (miš) Bend 13|13 B3 Početak 63,012,567 bp Kraj 63,036,096 bp
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • phosphoric ester hydrolase activity • vezivanje identičnih proteina • hydrolase activity • catalytic activity • monosaccharide binding • AMP binding • GO:0098519, GO:0098518 phosphatase activity • fructose 1,6-bisphosphate 1-phosphatase activity Ćelijska komponenta • citoplazma • Egzosom • citosol • jedro Biološki proces • fructose metabolic process • fructose 6-phosphate metabolic process • cellular response to magnesium ion • metabolizam • GO:0098501, GO:0098502, GO:0006286 Defosforilacija • regulation of gluconeogenesis • negative regulation of cell growth • protein homotetramerization • negative regulation of Ras protein signal transduction • Glukoneogeneza • sucrose biosynthetic process • fructose 1,6-bisphosphate metabolic process • carbohydrate metabolic process • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of glycolytic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2203	14121
Ensembl	ENSG00000165140	ENSMUSG00000069805
UniProt	P09467	Q9QXD6
RefSeq (mRNK)	NM_000507 NM_001127628	NM_019395
RefSeq (bjelančevina)	NP_000498 NP_001121100	NP_062268
Lokacija (UCSC)	Chr 9: 94.6 – 94.64 Mb	Chr 13: 63.01 – 63.04 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 338 aminokiselina, a molekulska težina 36.842 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MADQAPFDTD		VNTLTRFVME		EGRKARGTGE		LTQLLNSLCT		AVKAISSAVR
KAGIAHLYGI		AGSTNVTGDQ		VKKLDVLSND		LVMNMLKSSF		ATCVLVSEED
KHAIIVEPEK		RGKYVVCFDP		LDGSSNIDCL		VSVGTIFGIY		RKKSTDEPSE
KDALQPGRNL		VAAGYALYGS		ATMLVLAMDC		GVNCFMLDPA		IGEFILVDKD
VKIKKKGKIY		SLNEGYARDF		DPAVTEYIQR		KKFPPDNSAP		YGARYVGSMV
ADVHRTLVYG		GIFLYPANKK		SPNGKLRLLY		ECNPMAYVME		KAGGMATTGK
EAVLDVIPTD		IHQRAPVILG		SPDDVLEFLK		VYEKHSAQ

Funkcija

Fruktoza 1,6-bisfosfataza 1, a glukoproteinogenezni regulacijski enzim, koji katalizira hidrolizira fruktoza 1,6-bisfosfat do fruktoza 6-fosfata i neorganskog fosfata. Nedostatak fruktoza-1,6-difosfataze povezan je sa hipoglikemijom i metaboličkom acidozom.

Dopunska literatura

• Yáñez AJ, Bertinat R, Spichiger C, Carcamo JG, de Los Angeles García M, Concha II, Nualart F, Slebe JC (Oct 2005). "Novel expression of liver FBPase in Langerhans islets of human and rat pancreas". Journal of Cellular Physiology. 205 (1): 19–24. doi:10.1002/jcp.20407. hdl:10533/176131. PMID 15965961. S2CID 40822845.
• Faiyaz-Ul-Haque M, Al-Owain M, Al-Dayel F, Al-Hassnan Z, Al-Zaidan H, Rahbeeni Z, Al-Sayed M, Balobaid A, Cluntun A, Toulimat M, Abalkhail H, Peltekova I, Zaidi SH (Dec 2009). "Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency". European Journal of Pediatrics. 168 (12): 1467–71. doi:10.1007/s00431-009-0953-9. PMID 19259699. S2CID 23777808.
• Kikawa Y, Inuzuka M, Takano T, Shigematsu Y, Nakai A, Yamamoto Y, Jin BY, Koga J, Taketo A, Sudo M (Mar 1994). "cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency". Biochemical and Biophysical Research Communications. 199 (2): 687–93. doi:10.1006/bbrc.1994.1283. PMID 8135811.
• Besançon F, Just J, Bourgeade MF, Van Weyenbergh J, Solomon D, Guillozo H, Wietzerbin J, Cayre YE (Aug 1997). "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase". Journal of Interferon & Cytokine Research. 17 (8): 461–7. doi:10.1089/jir.1997.17.461. PMID 9282826.
• Gizak A, Maciaszczyk-Dziubinska E, Jurowicz M, Rakus D (Nov 2009). "Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence". Proteins. 77 (2): 262–7. doi:10.1002/prot.22506. PMID 19626708. S2CID 22934928.
• Zhang Y, Liang JY, Huang S, Ke H, Lipscomb WN (Feb 1993). "Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase". Biochemistry. 32 (7): 1844–57. doi:10.1021/bi00058a019. PMID 8382525.
• Visinoni S, Khalid NF, Joannides CN, Shulkes A, Yim M, Whitehead J, Tiganis T, Lamont BJ, Favaloro JM, Proietto J, Andrikopoulos S, Fam BC (maj 2012). "The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity". Diabetes. 61 (5): 1122–32. doi:10.2337/db11-1511. PMC 3331739. PMID 22517657.
• Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC (Jan 2010). "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis". Oncogene. 29 (3): 442–50. doi:10.1038/onc.2009.332. PMID 19881551.
• Kikawa Y, Inuzuka M, Jin BY, Kaji S, Koga J, Yamamoto Y, Fujisawa K, Hata I, Nakai A, Shigematsu Y, Mizunuma H, Taketo A, Mayumi M, Sudo M (Oct 1997). "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency". American Journal of Human Genetics. 61 (4): 852–61. doi:10.1086/514875. PMC 1715983. PMID 9382095.