DPYSL3

DPYSL3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4BKN, 4CNS, 4CNT, 4CNU
Identifikatori
Aliasi	DPYSL3
Vanjski ID-jevi	OMIM: 601168 MGI: 1349762 HomoloGene: 20361 GeneCards: DPYSL3
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	147,510,068 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	43,571,351 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• SH3 domain binding; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; • chondroitin sulfate binding; • hydrolase activity; • filamin binding;
Ćelijska komponenta	• citoplazma; • cell body; • filamentous actin; • citosol; • projekcija ćelije; • exocytic vesicle; • growth cone; • lamellipodium; • Vanćelijsko; • sinapsa;
Biološki proces	• negative regulation of neuron projection development; • regulation of cell migration; • regulation of neuron projection development; • neuron development; • actin filament bundle assembly; • negative regulation of cell migration; • response to axon injury; • actin crosslink formation; • positive regulation of neuron projection development; • protein homooligomerization; • positive regulation of filopodium assembly; • cellular response to cytokine stimulus;
	Izvori:Amigo / QuickGO
Ortolozi
	1809
	22240
	ENSG00000113657
	ENSMUSG00000024501
	Q14195
	Q62188
	NM_001197294; NM_001387
	NM_001136086; NM_001291455; NM_009468
	NP_001184223; NP_001378
	NP_001129558; NP_001278384; NP_033494
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Dihidropirimidinazi-srodni protein 3 jest enzim koji je kod ljudi kodiran genom DPYSL3.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 570 aminokiselina, а molekulska težina 61.963 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSYQGKKNIP	RITSDRLLIK	GGRIVNDDQS	FYADIYMEDG	LIKQIGDNLI
VPGGVKTIEA	NGKMVIPGGI	DVHTHFQMPY	KGMTTVDDFF	QGTKAALAGG
TTMIIDHVVP	EPESSLTEAY	EKWREWADGK	SCCDYALHVD	ITHWNDSVKQ
EVQNLIKDKG	VNSFMVYMAY	KDLYQVSNTE	LYEIFTCLGE	LGAIAQVHAE
NGDIIAQEQT	RMLEMGITGP	EGHVLSRPEE	LEAEAVFRAI	TIASQTNCPL
YVTKVMSKSA	ADLISQARKK	GNVVFGEPIT	ASLGIDGTHY	WSKNWAKAAA
FVTSPPLSPD	PTTPDYINSL	LASGDLQLSG	SAHCTFSTAQ	KAIGKDNFTA
IPEGTNGVEE	RMSVIWDKAV	ATGKMDENQF	VAVTSTNAAK	IFNLYPRKGR
ISVGSDSDLV	IWDPDAVKIV	SAKNHQSAAE	YNIFEGMELR	GAPLVVICQG
KIMLEDGNLH	VTQGAGRFIP	CSPFSDYVYK	RIKARRKMAD	LHAVPRGMYD
GPVFDLTTTP	KGGTPAGSAR	GSPTRPNPPV	RNLHQSGFSL	SGTQVDEGVR
SASKRIVAPP	GGRSNITSLS

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113657 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024501 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
^ Gaetano C, Matsuo T, Thiele CJ (Jun 1997). "Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells". J Biol Chem. 272 (18): 12195–201. doi:10.1074/jbc.272.18.12195. PMID 9115293.
^ "Entrez Gene: DPYSL3 dihydropyrimidinase-like 3".
^ "UniProt, Q14195" (jezik: engleski). Pristupljeno 14. 10. 2021.

Dopunska literatura

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Inagaki H, Kato Y, Hamajima N, et al. (2000). "Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system". Histochem. Cell Biol. 113 (1): 37–41. doi:10.1007/s004180050005. PMID 10664068. S2CID 11121195.
Matsuo T, Stauffer JK, Walker RL, et al. (2000). "Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts". J. Biol. Chem. 275 (22): 16560–8. doi:10.1074/jbc.M001312200. PMID 10748015.
Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
Weitzdoerfer R, Fountoulakis M, Lubec G (2002). Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain. J. Neural Transm. Suppl. str. 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN 978-3-211-83704-7. PMID 11771764.
Franken S, Junghans U, Rosslenbroich V, et al. (2003). "Collapsin response mediator proteins of neonatal rat brain interact with chondroitin sulfate". J. Biol. Chem. 278 (5): 3241–50. doi:10.1074/jbc.M210181200. PMID 12444086.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rosslenbroich V, Dai L, Franken S, et al. (2003). "Subcellular localization of collapsin response mediator proteins to lipid rafts". Biochem. Biophys. Res. Commun. 305 (2): 392–9. doi:10.1016/S0006-291X(03)00754-X. PMID 12745088.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Choi YL, Kim CJ, Matsuo T, et al. (2005). "HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors". J. Neurooncol. 73 (1): 19–27. doi:10.1007/s11060-004-3013-3. PMID 15933812. S2CID 25655752.
Cole AR, Causeret F, Yadirgi G, et al. (2006). "Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo". J. Biol. Chem. 281 (24): 16591–8. doi:10.1074/jbc.M513344200. PMC 1805471. PMID 16611631.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113657 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024501 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973361-5] Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.

[pmid9115293-6] Gaetano C, Matsuo T, Thiele CJ (Jun 1997). "Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells". J Biol Chem. 272 (18): 12195–201. doi:10.1074/jbc.272.18.12195. PMID 9115293.

[entrez-7] "Entrez Gene: DPYSL3 dihydropyrimidinase-like 3".

[UniProt-8] "UniProt, Q14195" (jezik: engleski). Pristupljeno 14. 10. 2021.

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