Protein 1 sa DEP domenom jest protein koji je kod ljudi kodiran genom DEPDC1 sa hromosoma 1.[5]

DEPDC1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2YSR

Identifikatori
AliasiDEPDC1
Vanjski ID-jeviOMIM: 612002 MGI: 1923381 HomoloGene: 9834 GeneCards: DEPDC1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za DEPDC1
Genomska lokacija za DEPDC1
Bend1p31.3Početak68,474,152 bp[1]
Kraj68,497,221 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za DEPDC1
Genomska lokacija za DEPDC1
Bend3|3 H4Početak159,201,070 bp[2]
Kraj159,235,592 bp[2]
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
GO:0005097, GO:0005099, GO:0005100 GTPase activator activity
Ćelijska komponenta transcription repressor complex
jedro
Biološki proces GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
GO:0007243 intracellular signal transduction
GO:0045996 negative regulation of transcription, DNA-templated
GO:0009373 regulation of transcription, DNA-templated
transcription, DNA-templated
GO:0072468 Transdukcija signala
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_017779
NM_001114120

NM_001172092
NM_001172093
NM_029523

RefSeq (bjelančevina)

NP_001107592
NP_060249

NP_001165563
NP_001165564
NP_083799

Lokacija (UCSC)Chr 1: 68.47 – 68.5 MbChr 3: 159.2 – 159.24 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Amiokiselininska sekvenca

uredi

Dužina polipeptidnog lanca je 811 aminokiselina, a molekulska težina 92.960 Da.[6]

1020304050
MESQGVPPGPYRATKLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAV
DWLYDLLRNNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSENVDDN
NQLFRFPATSPLKTLPRRYPELRKNNIENFSKDKDSIFKLRNLSRRTPKR
HGLHLSQENGEKIKHEIINEDQENAIDNRELSQEDVEEVWRYVILIYLQT
ILGVPSLEEVINPKQVIPQYIMYNMANTSKRGVVILQNKSDDLPHWVLSA
MKCLANWPRSNDMNNPTYVGFERDVFRTIADYFLDLPEPLLTFEYYELFV
NILVVCGYITVSDRSSGIHKIQDDPQSSKFLHLNNLNSFKSTECLLLSLL
HREKNKEESDSTERLQISNPGFQERCAKKMQLVNLRNRRVSANDIMGGSC
HNLIGLSNMHDLSSNSKPRCCSLEGIVDVPGNSSKEASSVFHQSFPNIEG
QNNKLFLESKPKQEFLLNLHSEENIQKPFSAGFKRTSTLTVQDQEELCNG
KCKSKQLCRSQSLLLRSSTRRNSYINTPVAEIIMKPNVGQGSTSVQTAME
SELGESSATINKRLCKSTIELSENSLLPASSMLTGTQSLLQPHLERVAID
ALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPKLHDAMGTRSLMIHTF
SRCVLCCAEEVDLDELLAGRLVSFLMDHHQEILQVPSYLQTAVEKHLDYL
KKGHIENPGDGLFAPLPTYSYCKQISAQEFDEQKVSTSQAAIAELLENII
KNRSLPLKEKRKKLKQFQKEYPLIYQKRFPTTESEAALFGDKPTIKQPML
ILRKPKFRSLR

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000024526 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028175 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DEP domain containing 1". Pristupljeno 7. 7. 2013.
  6. ^ "UniProt, Q5TB30" (jezik: engleski). Pristupljeno 24. 11. 2021.

Vanjski linkovi

uredi
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DEP domain-containing protein 1A (DEPDC1)