CREG1

Protein CREG1 (ćelijski represor E1A-stimuliranih gena 1) jest protein koji je kod ljudi kodiran genom CREG1 sa hromosoma 1.

CREG1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1XHN
Identifikatori
Aliasi	CREG1
Vanjski ID-jevi	OMIM: 618055 MGI: 1344382 HomoloGene: 31199 GeneCards: CREG1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q24.2 Početak 167,529,117 bp Kraj 167,553,805 bp
Lokacija gena (miš) Hrom. Hromosom 1 (miš) Bend 1|1 H2.3 Početak 165,591,315 bp Kraj 165,602,877 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • transcription factor binding • GO:0001106 transcription corepressor activity Ćelijska komponenta • Egzosom • transcription regulator complex • extracellular region • Vanćelijsko • azurophil granule lumen Biološki proces • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • multicellular organism development • regulation of growth • Ćelijska proliferacija • GO:0009373 regulation of transcription, DNA-templated • negative regulation of nucleic acid-templated transcription • neutrophil degranulation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8804	433375
Ensembl	ENSG00000143162	ENSMUSG00000040713
UniProt	O75629	O88668
RefSeq (mRNK)	NM_003851	NM_011804
RefSeq (bjelančevina)	NP_003842	NP_035934
Lokacija (UCSC)	Chr 1: 167.53 – 167.55 Mb	Chr 1: 165.59 – 165.6 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 220 aminokiselina, a molekulska težina 24.075 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAGLSRGSAR		ALLAALLAST		LLALLVSPAR		GRGGRDHGDW		DEASRLPPLP
PREDAARVAR		FVTHVSDWGA		LATISTLEAV		RGRPFADVLS		LSDGPPGAGS
GVPYFYLSPL		QLSVSNLQEN		PYATLTMTLA		QTNFCKKHGF		DPQSPLCVHI
MLSGTVTKVN		ETEMDIAKHS		LFIRHPEMKT		WPSSHNWFFA		KLNITNIWVL
DYFGGPKIVT		PEEYYNVTVQ

Funkcija

Protein adenovirusa E1A istovremeno aktivira i potiskuje ekspresiju gena, kako bi promovirao ćelijsku proliferaciju i inhibirao diferencijaciju. Protein kodiran ovim genom antagonizira transkripcijsku aktivaciju i ćelijsku transformaciju pomoću E1A. Ovaj protein dijeli ograničenu sličnost sekvence sa E1A i vezuje se za opći transkripcijski faktor TBP i tumorski supresor pRb in vitro. Ovaj gen može doprinijeti transkripcijskoj kontroli rasta i ćelijske diferencijacije.

Dopunska literatura

• Veal E, Groisman R, Eisenstein M, Gill G (2000). "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells". Oncogene. 19 (17): 2120–8. doi:10.1038/sj.onc.1203529. PMID 10815803.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Di Bacco A, Gill G (2003). "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor". Oncogene. 22 (35): 5436–45. doi:10.1038/sj.onc.1206670. PMID 12934103.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Sacher M, Di Bacco A, Lunin VV, et al. (2006). "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18326–31. doi:10.1073/pnas.0505071102. PMC 1317909. PMID 16344469.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

Vanjski linkovi

• Lokacija ljudskog genoma CREG1 i stranica sa detaljima o genu CREG1 u UCSC Genome Browseru.