CLK3

CLK3
Identifikatori
Aliasi
Vanjski ID-jevi	GeneCards: [1]
Ortolozi
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	Wikipodaci
Pogledaj/uredi – čovjek

Dvojnospecifična protein-kinaza CLK3 je enzim koji je kod ljudi kodiran genom CLK3.^[1]^[2] CLK3 kodira serin/treonin tip proteinskih kinaza sa nekonzrviranim N-terminalnim domenom. Duga i kratka izoforma (phclk3 i pclk3/152) nastaju iz alternativne prerade i koegzistiraju u različitim tkivima. Izoforma phclk3/152 nema domen kinaze.^[3]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 638 aminokiselina, a molekulska težina 73.515 Da.^[4].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MPVLSARRRE	LADHAGSGRR	SGPSPTARSG	PHLSALRAQP	ARAAHLSGRG
TYVRRDTAGG	GPGQARPLGP	PGTSLLGRGA	RRSGEGWCPG	AFESGARAAR
PPSRVEPRLA	TAASREGAGL	PRAEVAAGSG	RGARSGEWGL	AAAGAWETMH
HCKRYRSPEP	DPYLSYRWKR	RRSYSREHEG	RLRYPSRREP	PPRRSRSRSH
DRLPYQRRYR	ERRDSDTYRC	EERSPSFGED	YYGPSRSRHR	RRSRERGPYR
TRKHAHHCHK	RRTRSCSSAS	SRSQQSSKRS	SRSVEDDKEG	HLVCRIGDWL
QERYEIVGNL	GEGTFGKVVE	CLDHARGKSQ	VALKIIRNVG	KYREAARLEI
NVLKKIKEKD	KENKFLCVLM	SDWFNFHGHM	CIAFELLGKN	TFEFLKENNF
QPYPLPHVRH	MAYQLCHALR	FLHENQLTHT	DLKPENILFV	NSEFETLYNE
HKSCEEKSVK	NTSIRVADFG	SATFDHEHHT	TIVATRHYRP	PEVILELGWA
QPCDVWSIGC	ILFEYYRGFT	LFQTHENREH	LVMMEKILGP	IPSHMIHRTR
KQKYFYKGGL	VWDENSSDGR	YVKENCKPLK	SYMLQDSLEH	VQLFDLMRRM
LEFDPAQRIT	LAEALLHPFF	AGLTPEERSF	HTSRNPSR

Reference

^ Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.
^ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501.
^ "Entrez Gene: CLK3 CDC-like kinase 3".
^ "UniProt, P49761". Pristupljeno 13. 7. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Duncan PI, Stojdl DF, Marius RM, et al. (1998). "The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing". Exp. Cell Res. 241 (2): 300–8. doi:10.1006/excr.1998.4083. PMID 9637771.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

Vanjski linkovi

Clk dual-specificity kinases na US National Library of Medicine Medical Subject Headings (MeSH)
Lokacija ljudskog genoma CLK3 i stranica sa detaljima o genu CLK3 u UCSC Genome Browseru.

[pmid7990150-1] Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.

[pmid9856501-2] Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501.

[entrez-3] "Entrez Gene: CLK3 CDC-like kinase 3".

[UniProt-4] "UniProt, P49761". Pristupljeno 13. 7. 2021.

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