CHPF

CHPF
Identifikatori
Aliasi	CHPF
Vanjski ID-jevi	OMIM: 610405 MGI: 106576 HomoloGene: 11574 GeneCards: CHPF
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	219,543,809 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	75,455,951 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • acetylgalactosaminyltransferase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • glycosyltransferase activity; • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • Golgi cisterna membrane; • citosol; • Golđijeva membrana; • mitochondrial matrix; • Golđijev aparat; • mitohondrija; • membrana;
Biološki proces	• chondroitin sulfate biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	79586
	74241
	ENSG00000123989
	ENSMUSG00000032997
	Q8IZ52
	Q6IQX7
	NM_001195731; NM_024536
	NM_001001565; NM_001001566
	NP_001182660; NP_078812
	NP_001001565; NP_001001566
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hondroitin sulfat-sintaza 2 jest enzim koji je kod ljudi kodiran genom CHPF sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 775 aminokiselina, a molekulska težina 85.467 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRASLLLSVL	RPAGPVAVGI	SLGFTLSLLS	VTWVEEPCGP	GPPQPGDSEL
PPRGNTNAAR	RPNSVQPGAE	REKPGAGEGA	GENWEPRVLP	YHPAQPGQAA
KKAVRTRYIS	TELGIRQRLL	VAVLTSQTTL	PTLGVAVNRT	LGHRLERVVF
LTGARGRRAP	PGMAVVTLGE	ERPIGHLHLA	LRHLLEQHGD	DFDWFFLVPD
TTYTEAHGLA	RLTGHLSLAS	AAHLYLGRPQ	DFIGGEPTPG	RYCHGGFGVL
LSRMLLQQLR	PHLEGCRNDI	VSARPDEWLG	RCILDATGVG	CTGDHEGVHY
SHLELSPGEP	VQEGDPHFRS	ALTAHPVRDP	VHMYQLHKAF	ARAELERTYQ
EIQELQWEIQ	NTSHLAVDGD	QAAAWPVGIP	APSRPASRFE	VLRWDYFTEQ
HAFSCADGSP	RCPLRGADRA	DVADVLGTAL	EELNRRYHPA	LRLQKQQLVN
GYRRFDPARG	MEYTLDLQLE	ALTPQGGRRP	LTRRVQLLRP	LSRVEILPVP
YVTEASRLTV	LLPLAAAERD	LAPGFLEAFA	TAALEPGDAA	AALTLLLLYE
PRQAQRVAHA	DVFAPVKAHV	AELERRFPGA	RVPWLSVQTA	APSPLRLMDL
LSKKHPLDTL	FLLAGPDTVL	TPDFLNRCRM	HAISGWQAFF	PMHFQAFHPA
VAPPQGPGPP	ELGRDTGRFD	RQAASEACFY	NSDYVAARGR	LAAASEQEEE
LLESLDVYEL	FLHFSSLHVL	RAVEPALLQR	YRAQTCSARL	SEDLYHRCLQ
SVLEGLGSRT	QLAMLLFEQE	QGNST

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123989 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032997 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ Kitagawa H, Izumikawa T, Uyama T, Sugahara K (Jun 2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J Biol Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
^ "Entrez Gene: CHPF chondroitin polymerizing factor".
^ "UniProt, Q8IZ52" (jezik: engleski). Pristupljeno 16. 11. 2021.

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yada T, Gotoh M, Sato T, et al. (2003). "Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities". J. Biol. Chem. 278 (32): 30235–47. doi:10.1074/jbc.M303657200. PMID 12761225.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi

Lokacija ljudskog genoma CHPF i stranica sa detaljima o genu CHPF u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123989 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032997 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid12716890-6] Kitagawa H, Izumikawa T, Uyama T, Sugahara K (Jun 2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J Biol Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.

[entrez-7] "Entrez Gene: CHPF chondroitin polymerizing factor".

[UniProt-8] "UniProt, Q8IZ52" (jezik: engleski). Pristupljeno 16. 11. 2021.

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