CGAS

CGAS
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4LEW, 4KM5, 4O67, 4MKP, 4LEV, 4O68, 4O69
Identifikatori
Aliasi	CGAS
Vanjski ID-jevi	OMIM: 613973 MGI: 2442261 HomoloGene: 51384 GeneCards: CGAS
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	73,452,297 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	78,350,519 bp
Ontologija gena
Molekularna funkcija	• nucleotidyltransferase activity; • nucleotide binding; • vezivanje iona metala; • GTP binding; • aktivnost sa transferazom; • ATP binding; • vezivanje sa DNK; • 2',3'-cyclic GMP-AMP synthase activity; • double-stranded DNA binding; • chromatin binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • citosol;
Biološki proces	• immune system process; • cyclic nucleotide biosynthetic process; • cellular response to exogenous dsRNA; • Urođeni imunski sistem; • activation of innate immune response; • defense response to virus; • positive regulation of defense response to virus by host; • cellular response to DNA damage stimulus; • positive regulation of type I interferon production; • paracrine signaling; • positive regulation of cellular senescence; • positive regulation of cGMP-mediated signaling; • positive regulation of cAMP-mediated signaling; • regulation of immunoglobulin production; • determination of adult lifespan; • regulation of type I interferon production; • regulation of immune response; • regulation of T cell activation;
	Izvori:Amigo / QuickGO
Ortolozi
	115004
	214763
	ENSG00000164430
	ENSMUSG00000032344
	Q8N884
	Q8C6L5
	NM_138441
	NM_173386
	NP_612450
	NP_775562
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cikllična GMP-AMP sintaza jest protein koji je kod ljudi kodiran genom CGAS.^[5] To je enzim, nukleotidiltransferaza, cGMP-cAMP sintaza.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 522 aminokiseline, а molekulska težina 58.814 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MQPWHGKAMQ	RASEAGATAP	KASARNARGA	PMDPTESPAA	PEAALPKAGK
FGPARKSGSR	QKKSAPDTQE	RPPVRATGAR	AKKAPQRAQD	TQPSDATSAP
GAEGLEPPAA	REPALSRAGS	CRQRGARCST	KPRPPPGPWD	VPSPGLPVSA
PILVRRDAAP	GASKLRAVLE	KLKLSRDDIS	TAAGMVKGVV	DHLLLRLKCD
SAFRGVGLLN	TGSYYEHVKI	SAPNEFDVMF	KLEVPRIQLE	EYSNTRAYYF
VKFKRNPKEN	PLSQFLEGEI	LSASKMLSKF	RKIIKEEIND	IKDTDVIMKR
KRGGSPAVTL	LISEKISVDI	TLALESKSSW	PASTQEGLRI	QNWLSAKVRK
QLRLKPFYLV	PKHAKEGNGF	QEETWRLSFS	HIEKEILNNH	GKSKTCCENK
EEKCCRKDCL	KLMKYLLEQL	KERFKDKKHL	DKFSSYHVKT	AFFHVCTQNP
QDSQWDRKDL	GLCFDNCVTY	FLQCLRTEKL	ENYFIPEFNL	FSSNLIDKRS
KEFLTKQIEY	ERNNEFPVFD	EF

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164430 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032344 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]". Pristupljeno 12. 9. 2020.
^ "UniProt, Q8N884" (jezik: engleski). Pristupljeno 8. 10. 2021.

Vanjski linkovi

PDBe-KB provides an overview of all the structure information available in the PDB for Human Cyclic GMP-AMP synthase (MB21D1)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164430 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032344 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]". Pristupljeno 12. 9. 2020.

[UniProt-6] "UniProt, Q8N884" (jezik: engleski). Pristupljeno 8. 10. 2021.

[5]

[1]

[2]

[3]

[4]

[6]