CD5L

CD5L
Identifikatori
Aliasi	CD5L
Vanjski ID-jevi	OMIM: 602592 MGI: 1334419 HomoloGene: 55936 GeneCards: CD5L
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	157,898,256 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	87,278,380 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• scavenger receptor activity;
Ćelijska komponenta	• citoplazma; • extracellular region; • Egzosom; • blood microparticle; • membrana; • Vanćelijsko; • ćelijska membrana; • cell surface;
Biološki proces	• cellular defense response; • inflammatory response; • receptor-mediated endocytosis; • immune system process; • GO:0097285 apoptoza; • vesicle-mediated transport; • regulation of complement activation; • positive regulation of complement-dependent cytotoxicity; • Endocitoza;
	Izvori:Amigo / QuickGO
Ortolozi
	922
	11801
	ENSG00000073754
	ENSMUSG00000015854
	O43866
	Q9QWK4
	NM_005894; NM_001347698
	NM_009690
	NP_001334627; NP_005885
	NP_033820
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Antigenoliki CD5 jest protein koji je kod ljudi kodiran genom CD5L sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 347 aminokiselina, a molekulska težina 38.088 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MALLFSLILA	ICTRPGFLAS	PSGVRLVGGL	HRCEGRVEVE	QKGQWGTVCD
DGWDIKDVAV	LCRELGCGAA	SGTPSGILYE	PPAEKEQKVL	IQSVSCTGTE
DTLAQCEQEE	VYDCSHDEDA	GASCENPESS	FSPVPEGVRL	ADGPGHCKGR
VEVKHQNQWY	TVCQTGWSLR	AAKVVCRQLG	CGRAVLTQKR	CNKHAYGRKP
IWLSQMSCSG	REATLQDCPS	GPWGKNTCNH	DEDTWVECED	PFDLRLVGGD
NLCSGRLEVL	HKGVWGSVCD	DNWGEKEDQV	VCKQLGCGKS	LSPSFRDRKC
YGPGVGRIWL	DNVRCSGEEQ	SLEQCQHRFW	GFHDCTHQED	VAVICSG

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073754 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015854 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gebe JA, Kiener PA, Ring HZ, Li X, Francke U, Aruffo A (Apr 1997). "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins". J Biol Chem. 272 (10): 6151–8. doi:10.1074/jbc.272.10.6151. PMID 9045627.
^ "Entrez Gene: CD5L CD5 molecule-like".
^ "UniProt, O43866" (jezik: en.). Pristupljeno 8. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Vanjski linkovi

Lokacija ljudskog genoma CD5L i stranica sa detaljima o genu CD5L u UCSC Genome Browseru.

Dopunska literatura

Tissot JD, Schifferli JA, Hochstrasser DF, et al. (1994). "Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide". J. Immunol. Methods. 173 (1): 63–75. doi:10.1016/0022-1759(94)90284-4. PMID 8034987.
Tissot JD, Sanchez JC, Vuadens F, et al. (2002). "IgM are associated to Sp alpha (CD5 antigen-like)". Electrophoresis. 23 (7–8): 1203–6. doi:10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1. PMID 11981870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sarrias MR, Roselló S, Sánchez-Barbero F, et al. (2005). "A role for human Sp alpha as a pattern recognition receptor". J. Biol. Chem. 280 (42): 35391–8. doi:10.1074/jbc.M505042200. PMID 16030018.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073754 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015854 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9045627-5] Gebe JA, Kiener PA, Ring HZ, Li X, Francke U, Aruffo A (Apr 1997). "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins". J Biol Chem. 272 (10): 6151–8. doi:10.1074/jbc.272.10.6151. PMID 9045627.

[entrez-6] "Entrez Gene: CD5L CD5 molecule-like".

[UniProt-7] "UniProt, O43866" (jezik: en.). Pristupljeno 8. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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