CCAR1

CCAR1
Identifikatori
Aliasi	CCAR1
Vanjski ID-jevi	OMIM: 612569 MGI: 1914750 HomoloGene: 10086 GeneCards: CCAR1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	68,792,377 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	62,628,065 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001106 transcription corepressor activity; • nuclear receptor coactivator activity; • GO:0001105 transcription coactivator activity; • vezivanje sa RNK; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Ćelijska komponenta	• citoplazma; • perinuklearno područje citoplazme; • nukleoplazma; • jedro;
Biološki proces	• positive regulation of cell migration; • mRNA splicing, via spliceosome; • ćelijski ciklus; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of cell population proliferation; • GO:0097285 apoptoza; • negative regulation of nucleic acid-templated transcription; • positive regulation of nucleic acid-templated transcription;
	Izvori:Amigo / QuickGO
Ortolozi
	55749
	67500
	ENSG00000060339
	ENSMUSG00000020074
	Q8IX12
	Q8CH18
	NM_001282959; NM_001282960; NM_018237
	NM_026201
	NP_001269888; NP_001269889; NP_060707
	NP_080477
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Regulatorni protein 1 ćelijske diobe I apoptoze je protein koji je kod ljudi kodiran genom CCAR1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca proteina je 375 aminokiselina, a molekulska težina 132.821.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAQFGGQKNP	PWATQFTATA	VSQPAALGVQ	QPSLLGASPT	IYTQQTALAA
AGLTTQTPAN	YQLTQTAALQ	QQAAAAAAAL	QQQYSQPQQA	LYSVQQQLQQ
PQQTLLTQPA	VALPTSLSLS	TPQPTAQITV	SYPTPRSSQQ	QTQPQKQRVF
TGVVTKLHDT	FGFVDEDVFF	QLSAVKGKTP	QVGDRVLVEA	TYNPNMPFKW
NAQRIQTLPN	QNQSQTQPLL	KTPPAVLQPI	APQTTFGVQT	QPQPQSLLQA
QISAASITPL	LQTQPQPLLQ	QPQQKAGLLQ	PPVRIVSQPQ	PARRLDPPSR
FSGRNDRGDQ	VPNRKDDRSR	ERERERRRSR	ERSPQRKRSR	ERSPRRERER
SPRRVRRVVP	RYTVQFSKFS	LDCPSCDMME	LRRRYQNLYI	PSDFFDAQFT
WVDAFPLSRP	FQLGNYCNFY	VMHREVESLE	KNMAILDPPD	ADHLYSAKVM
LMASPSMEDL	YHKSCALAED	PQELRDGFQH	PARLVKFLVG	MKGKDEAMAI
GGHWSPSLDG	PDPEKDPSVL	IKTAIRCCKA	LTGIDLSVCT	QWYRFAEIRY
HRPEETHKGR	TVPAHVETVV	LFFPDVWHCL	PTRSEWETLS	RGYKQQLVEK
LQGERKEADG	EQDEEEKDDG	EAKEISTPTH	WSKLDPKTMK	VNDLRKELES
RALSSKGLKS	QLIARLTKQL	KVEEQKEEQK	ELEKSEKEED	EDDDRKSEDD
KEEEERKRQE	EIERQRRERR	YILPDEPAII	VHPNWAAKSG	KFDCSIMSLS
VLLDYRLEDN	KEHSFEVSLF	AELFNEMLQR	DFGVRIYKSL	LSLPEKEDKK
EKDKKSKKDE	RKDKKEERDD	ETDEPKPKRR	KSGDDKDKKE	DRDERKKEDK
RKDDSKDDDE	TEEDNNQDEY	DPMEAEEAED	EEDDRDEEEM	TKRDDKRDIN
RYCKERPSKD	KEKEKTQMIT	INRDLLMAFV	YFDQSHCGYL	LEKDLEEILY
TLGLHLSRAQ	VKKLLNKVVL	RESCFYRKLT	DTSKDEENHE	ESESLQEDML
GNRLLLPTPT	VKQESKDVEE	NVGLIVYNGA	MVDVGSLLQK	LEKSEKVRAE
VEQKLQLLEE	KTDEDEKTIL	NLENSNKSLS	GELREVKKDL	SQLQENLKIS
ENMNLQFENQ	MNKTIRNLST	VMDEIHTVLK	KDNVKNEDKD	QKSKENGASV

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000060339 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020074 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U (Aug 2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". J Biol Chem. 278 (35): 33422–35. doi:10.1074/jbc.M303173200. PMID 12816952.
^ "Entrez Gene: CCAR1 cell division cycle and apoptosis regulator 1".
^ "UniProt, Q8IX12". Pristupljeno 30. 8. 2021.

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rishi AK, Zhang L, Yu Y, et al. (2006). "Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor". J. Biol. Chem. 281 (19): 13188–98. doi:10.1074/jbc.M512279200. PMID 16543231.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Zhang L, Levi E, Majumder P, et al. (2007). "Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo". Mol. Cancer Ther. 6 (5): 1661–72. doi:10.1158/1535-7163.MCT-06-0653. PMID 17513614.

Vanjski linkovi

Lokacija ljudskog genoma CCAR1 i stranica sa detaljima o genu CCAR1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000060339 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020074 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12816952-5] Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U (Aug 2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". J Biol Chem. 278 (35): 33422–35. doi:10.1074/jbc.M303173200. PMID 12816952.

[entrez-6] "Entrez Gene: CCAR1 cell division cycle and apoptosis regulator 1".

[UniProt-7] "UniProt, Q8IX12". Pristupljeno 30. 8. 2021.

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