CCAR1
Regulatorni protein 1 ćelijske diobe I apoptoze je protein koji je kod ljudi kodiran genom CCAR1.[5][6]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca proteina je 375 aminokiselina, a molekulska težina 132.821.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAQFGGQKNP | PWATQFTATA | VSQPAALGVQ | QPSLLGASPT | IYTQQTALAA | ||||
| AGLTTQTPAN | YQLTQTAALQ | QQAAAAAAAL | QQQYSQPQQA | LYSVQQQLQQ | ||||
| PQQTLLTQPA | VALPTSLSLS | TPQPTAQITV | SYPTPRSSQQ | QTQPQKQRVF | ||||
| TGVVTKLHDT | FGFVDEDVFF | QLSAVKGKTP | QVGDRVLVEA | TYNPNMPFKW | ||||
| NAQRIQTLPN | QNQSQTQPLL | KTPPAVLQPI | APQTTFGVQT | QPQPQSLLQA | ||||
| QISAASITPL | LQTQPQPLLQ | QPQQKAGLLQ | PPVRIVSQPQ | PARRLDPPSR | ||||
| FSGRNDRGDQ | VPNRKDDRSR | ERERERRRSR | ERSPQRKRSR | ERSPRRERER | ||||
| SPRRVRRVVP | RYTVQFSKFS | LDCPSCDMME | LRRRYQNLYI | PSDFFDAQFT | ||||
| WVDAFPLSRP | FQLGNYCNFY | VMHREVESLE | KNMAILDPPD | ADHLYSAKVM | ||||
| LMASPSMEDL | YHKSCALAED | PQELRDGFQH | PARLVKFLVG | MKGKDEAMAI | ||||
| GGHWSPSLDG | PDPEKDPSVL | IKTAIRCCKA | LTGIDLSVCT | QWYRFAEIRY | ||||
| HRPEETHKGR | TVPAHVETVV | LFFPDVWHCL | PTRSEWETLS | RGYKQQLVEK | ||||
| LQGERKEADG | EQDEEEKDDG | EAKEISTPTH | WSKLDPKTMK | VNDLRKELES | ||||
| RALSSKGLKS | QLIARLTKQL | KVEEQKEEQK | ELEKSEKEED | EDDDRKSEDD | ||||
| KEEEERKRQE | EIERQRRERR | YILPDEPAII | VHPNWAAKSG | KFDCSIMSLS | ||||
| VLLDYRLEDN | KEHSFEVSLF | AELFNEMLQR | DFGVRIYKSL | LSLPEKEDKK | ||||
| EKDKKSKKDE | RKDKKEERDD | ETDEPKPKRR | KSGDDKDKKE | DRDERKKEDK | ||||
| RKDDSKDDDE | TEEDNNQDEY | DPMEAEEAED | EEDDRDEEEM | TKRDDKRDIN | ||||
| RYCKERPSKD | KEKEKTQMIT | INRDLLMAFV | YFDQSHCGYL | LEKDLEEILY | ||||
| TLGLHLSRAQ | VKKLLNKVVL | RESCFYRKLT | DTSKDEENHE | ESESLQEDML | ||||
| GNRLLLPTPT | VKQESKDVEE | NVGLIVYNGA | MVDVGSLLQK | LEKSEKVRAE | ||||
| VEQKLQLLEE | KTDEDEKTIL | NLENSNKSLS | GELREVKKDL | SQLQENLKIS | ||||
| ENMNLQFENQ | MNKTIRNLST | VMDEIHTVLK | KDNVKNEDKD | QKSKENGASV | ||||
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000060339 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020074 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U (Aug 2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". J Biol Chem. 278 (35): 33422–35. doi:10.1074/jbc.M303173200. PMID 12816952.
- ^ "Entrez Gene: CCAR1 cell division cycle and apoptosis regulator 1".
- ^ "UniProt, Q8IX12". Pristupljeno 30. 8. 2021.
Dopunska literatura uredi
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rishi AK, Zhang L, Yu Y, et al. (2006). "Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor". J. Biol. Chem. 281 (19): 13188–98. doi:10.1074/jbc.M512279200. PMID 16543231.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Zhang L, Levi E, Majumder P, et al. (2007). "Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo". Mol. Cancer Ther. 6 (5): 1661–72. doi:10.1158/1535-7163.MCT-06-0653. PMID 17513614.
Vanjski linkovi uredi
- Lokacija ljudskog genoma CCAR1 i stranica sa detaljima o genu CCAR1 u UCSC Genome Browseru.