ATP5PO
Mitohondrijska podjedinica O ATP-sintaze jest enzim koji je kod ljudi kodiran genom ATP5PO sa hromosoma 21.[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 213 aminokiselina, a molekulska težina 23.277 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAAPAVSGLS | RQVRCFSTSV | VRPFAKLVRP | PVQVYGIEGR | YATALYSAAS | ||||
| KQNKLEQVEK | ELLRVAQILK | EPKVAASVLN | PYVKRSIKVK | SLNDITAKER | ||||
| FSPLTTNLIN | LLAENGRLSN | TQGVVSAFST | MMSVHRGEVP | CTVTSASPLE | ||||
| EATLSELKTV | LKSFLSQGQV | LKLEAKTDPS | ILGGMIVRIG | EKYVDMSVKT | ||||
| KIQKLGRAMR | EIV |
Funkcija
urediProtein kodiran ovim genom je komponenta F-tipa ATPaze pronađene u mitohondrijskom matriksu. ATPaze F tipa sastoje se od katalitskog jezgra i membranskog protonskog kanala. Čini se da je kodirani protein dio konektora koji povezuje ove dvije komponente i može biti uključen u prijenos konformacijskih promjena ili kondukciju protona.[5]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000241837 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022956 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "ATP5PO ATP synthase peripheral stalk subunit OSCP [ Homo sapiens (human) ]".
Dopunska literatura
uredi- Chen H, Morris MA, Rossier C, et al. (1996). "Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2". Genomics. 28 (3): 470–6. doi:10.1006/geno.1995.1176. PMID 7490082.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
- Aggeler R, Coons J, Taylor SW, et al. (2002). "A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies". J. Biol. Chem. 277 (37): 33906–12. doi:10.1074/jbc.M204538200. PMID 12110673.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Johnson KM, Chen X, Boitano A, et al. (2005). "Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423". Chem. Biol. 12 (4): 485–96. doi:10.1016/j.chembiol.2005.02.012. PMID 15850986.
Vanjski linkovi
uredi- Lokacija ljudskog genoma ATP5PO i stranica sa detaljima o genu ATP5PO u UCSC Genome Browseru.