APBB2

APBB2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1
Identifikatori
Aliasi	APBB2
Vanjski ID-jevi	OMIM: 602710 MGI: 108405 HomoloGene: 32079 GeneCards: APBB2
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	41,216,714 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	66,776,127 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • transcription factor binding; • amyloid-beta binding;
Ćelijska komponenta	• growth cone; • membrana; • citoplazma; • lamellipodium; • sinapsa; • jedro;
Biološki proces	• positive regulation of apoptotic process; • GO:0007243 intracellular signal transduction; • negative regulation of cell growth; • negative regulation of apoptotic process; • extracellular matrix organization; • axon guidance; • neuron migration; • GO:0009373 regulation of transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	323
	11787
	ENSG00000163697
	ENSMUSG00000029207
	Q92870
	Q9DBR4
NM_001166050; NM_001166051; NM_001166052; NM_001166053; NM_001166054;
	NM_004307; NM_173075; NM_001330656; NM_001330658
NM_001201413; NM_001201414; NM_001201415; NM_001201416; NM_009686;
	NM_001310626
NP_001159522; NP_001159523; NP_001159524; NP_001159525; NP_001159526;
	NP_001317585; NP_001317587; NP_004298; NP_775098
NP_001188342; NP_001188343; NP_001188344; NP_001188345; NP_001297555;
	NP_033816
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 2 porodice B amijeloidnog beta A4 protein-vezujućeg prekursora jest protein koji je kod ljudi kodiran genom APBB2 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 758 aminokiselina, а molekulska težina 83.374 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSEVLPADSG	VDTLAVFMAS	SGTTDVTNRN	SPATPPNTLN	LRSSHNELLN
AEIKHTETKN	STPPKCRKKY	ALTNIQAAMG	LSDPAAQPLL	GNGSANIKLV
KNGENQLRKA	AEQGQQDPNK	NLSPTAVINI	TSEKLEGKEP	HPQDSSSCEI
LPSQPRRTKS	FLNYYADLET	SARELEQNRG	NHHGTAEEKS	QPVQGQASTI
IGNGDLLLQK	PNRPQSSPED	GQVATVSSSP	ETKKDHPKTG	AKTDCALHRI
QNLAPSDEES	SWTTLSQDSA	SPSSPDETDI	WSDHSFQTDP	DLPPGWKRVS
DIAGTYYWHI	PTGTTQWERP	VSIPADLQGS	RKGSLSSVTP	SPTPENEKQP
WSDFAVLNGG	KINSDIWKDL	HAATVNPDPS	LKEFEGATLR	YASLKLRNAP
HPDDDDSCSI	NSDPEAKCFA	VRSLGWVEMA	EEDLAPGKSS	VAVNNCIRQL
SYCKNDIRDT	VGIWGEGKDM	YLILENDMLS	LVDPMDRSVL	HSQPIVSIRV
WGVGRDNGRD	FAYVARDKDT	RILKCHVFRC	DTPAKAIATS	LHEICSKIMA
ERKNAKALAC	SSLQERANVN	LDVPLQVDFP	TPKTELVQKF	HVQYLGMLPV
DKPVGMDILN	SAIENLMTSS	NKEDWLSVNM	NVADATVTVI	SEKNEEEVLV
ECRVRFLSFM	GVGKDVHTFA	FIMDTGNQRF	ECHVFWCEPN	AGNVSEAVQA
ACMLRYQKCL	VARPPSQKVR	PPPPPADSVT	RRVTTNVKRG	VLSLIDTLKQ
KRPVTEMP

Funkcija

Protein kodiran ovim genom stupa u interakciju sa citoplazmatskim domenima amiloid-beta (A4) prekursorskog proteina i amiloid-beta (A4) prekursorskog proteina 2. Ovaj protein sadrži dva vezujuća fosfotirozinska (PTB) domena, za koje se smatra da funkcioniraju u transdukciji signala.^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163697 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029207 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.
^ Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438. S2CID 31066473.
^ "UniProt, Q92870" (jezik: engleski). Pristupljeno 22. 10. 2021.
^ "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

Dopunska literatura

Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266.
Bruni P, Minopoli G, Brancaccio T, et al. (2002). "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression". J. Biol. Chem. 277 (38): 35481–8. doi:10.1074/jbc.M205227200. PMID 12089154.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chang Y, Tesco G, Jeong WJ, et al. (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1". J. Biol. Chem. 278 (51): 51100–7. doi:10.1074/jbc.M309561200. PMID 14527950.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li Y, Hollingworth P, Moore P, et al. (2006). "Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease". Hum. Mutat. 25 (3): 270–7. doi:10.1002/humu.20138. PMID 15714520. S2CID 28343972.
Lange A, Thon L, Mathieu S, Adam D (2005). "The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor". Biochem. Biophys. Res. Commun. 335 (2): 575–83. doi:10.1016/j.bbrc.2005.07.125. PMID 16083851.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hong Q, Hsu LJ, Schultz L, et al. (2007). "Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response". BMC Mol. Biol. 8: 50. doi:10.1186/1471-2199-8-50. PMC 1904229. PMID 17567906.

Vanjski linkovi

Lokacija ljudskog genoma APBB2 i stranica sa detaljima o genu APBB2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163697 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029207 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8955346-5] McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.

[pmid9585438-6] Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438. S2CID 31066473.

[UniProt-7] "UniProt, Q92870" (jezik: engleski). Pristupljeno 22. 10. 2021.

[entrez-8] "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

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