Član 2 porodice B amijeloidnog beta A4 protein-vezujućeg prekursora jest protein koji je kod ljudi kodiran genom APBB2 sa hromosoma 4.[5][6]

APBB2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1

Identifikatori
AliasiAPBB2
Vanjski ID-jeviOMIM: 602710 MGI: 108405 HomoloGene: 32079 GeneCards: APBB2
Lokacija gena (čovjek)
Hromosom 4 (čovjek)
Hrom.Hromosom 4 (čovjek)[1]
Hromosom 4 (čovjek)
Genomska lokacija za APBB2
Genomska lokacija za APBB2
Bend4p14-p13Početak40,810,027 bp[1]
Kraj41,216,714 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za APBB2
Genomska lokacija za APBB2
Bend5|5 C3.1Početak66,456,046 bp[2]
Kraj66,776,127 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 protein binding
transcription factor binding
amyloid-beta binding
Ćelijska komponenta growth cone
membrana
citoplazma
lamellipodium
sinapsa
Jedro
Biološki proces positive regulation of apoptotic process
GO:0007243 intracellular signal transduction
negative regulation of cell growth
negative regulation of apoptotic process
extracellular matrix organization
axon guidance
neuron migration
GO:0009373 regulation of transcription, DNA-templated
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001166050
NM_001166051
NM_001166052
NM_001166053
NM_001166054

NM_004307
NM_173075
NM_001330656
NM_001330658

NM_001201413
NM_001201414
NM_001201415
NM_001201416
NM_009686

NM_001310626

RefSeq (bjelančevina)
NP_001159522
NP_001159523
NP_001159524
NP_001159525
NP_001159526

NP_001317585
NP_001317587
NP_004298
NP_775098

NP_001188342
NP_001188343
NP_001188344
NP_001188345
NP_001297555

NP_033816

Lokacija (UCSC)Chr 4: 40.81 – 41.22 MbChr 5: 66.46 – 66.78 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 758 aminokiselina, а molekulska težina 83.374 Da.[7]

1020304050
MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLN
AEIKHTETKNSTPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLV
KNGENQLRKAAEQGQQDPNKNLSPTAVINITSEKLEGKEPHPQDSSSCEI
LPSQPRRTKSFLNYYADLETSARELEQNRGNHHGTAEEKSQPVQGQASTI
IGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTGAKTDCALHRI
QNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVS
DIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEKQP
WSDFAVLNGGKINSDIWKDLHAATVNPDPSLKEFEGATLRYASLKLRNAP
HPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQL
SYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRV
WGVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMA
ERKNAKALACSSLQERANVNLDVPLQVDFPTPKTELVQKFHVQYLGMLPV
DKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTVISEKNEEEVLV
ECRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQA
ACMLRYQKCLVARPPSQKVRPPPPPADSVTRRVTTNVKRGVLSLIDTLKQ
KRPVTEMP

Funkcija uredi

Protein kodiran ovim genom stupa u interakciju sa citoplazmatskim domenima amiloid-beta (A4) prekursorskog proteina i amiloid-beta (A4) prekursorskog proteina 2. Ovaj protein sadrži dva vezujuća fosfotirozinska (PTB) domena, za koje se smatra da funkcioniraju u transdukciji signala.[8]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163697 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029207 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.
  6. ^ Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438. S2CID 31066473.
  7. ^ "UniProt, Q92870" (jezik: engleski). Pristupljeno 22. 10. 2021.
  8. ^ "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

Dopunska literatura uredi

Vanjski linkovi uredi