AMOTL1

AMOTL1
Identifikatori
Aliasi	AMOTL1
Vanjski ID-jevi	OMIM: 614657 MGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	94,876,748 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	14,556,352 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina;
Ćelijska komponenta	• COP9 signalosome; • citosol; • apical plasma membrane; • GO:0016023 citoplazmatska vezikula; • lamellipodium; • bicellular tight junction; • međućelijske veze;
Biološki proces	• establishment of cell polarity involved in ameboidal cell migration; • Wnt-signalni put; • hippo signaling; • positive regulation of blood vessel endothelial cell migration; • actin cytoskeleton organization; • regulation of cell migration; • Angiogeneza;
	Izvori:Amigo / QuickGO
Ortolozi
	154810
	75723
	ENSG00000166025
	ENSMUSG00000013076
	Q8IY63
	Q9D4H4
	NM_001301007; NM_130847
	NM_001081395
	NP_001287936; NP_570899; NP_570899.1
	NP_001074864
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Angiomotinoliki protein 1 je protein koji je kod ljudi kodiran genom AMOTL1.^[5]^[6]

Aminokiselinska sekvenca

Protein kodiran ovim genom je protein periferne membrane koji je komponenta uskih mešućelijskih veze ili TJ. TJ tvore apikalna spojna struktura i djeluju na kontrolu paraćelijske propusnosti i održavanje ćelijske polarnosti. Ovaj protein je povezan sa angiomotinom, proteinom koji veže angiostatin i regulira migraciju endotelnih ćelija i stvaranje kapilarnih.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166025 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013076 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi:10.1074/jbc.M110154200. PMID 11733531.
^ ^a ^b "Entrez Gene: AMOTL1 angiomotin like 1".
^ "UniProt, Q8IY63". Pristupljeno 15. 8. 2021.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochim. Biophys. Acta. 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

Lokacija ljudskog genoma AMOTL1 i stranica sa detaljima o genu AMOTL1 u UCSC Genome Browseru.