ADGRL2

Latrofilin 2 jest protein koji je kod ljudi kodiran genom ADGRL2 sa hromosoma 1.

ADGRL2
Identifikatori
Aliasi	ADGRL2
Vanjski ID-jevi	OMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1p31.1 Početak 81,306,147 bp Kraj 81,993,932 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3|3 H3 Početak 148,815,583 bp Kraj 148,990,555 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • G protein-coupled receptor activity • transmembrane signaling receptor activity • latrotoxin receptor activity • signal transducer activity • carbohydrate binding Ćelijska komponenta • integral component of membrane • membrana • intracellular anatomical structure • integral component of plasma membrane • neuron projection Biološki proces • G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • GO:0072468 Transdukcija signala • adenylate cyclase-activating G protein-coupled receptor signaling pathway • brain development Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23266	99633
Ensembl	ENSG00000117114	ENSMUSG00000028184
UniProt	O95490	Q8JZZ7
RefSeq (mRNK)	NM_001297704 NM_001297705 NM_001297706 NM_012302 NM_001330645 NM_001350698 NM_001350699 NM_001366002 NM_001366003 NM_001366004 NM_001366005 NM_001366006 NM_001366007 NM_001366008 NM_001366009 NM_001393349 NM_001393350 NM_001393351 NM_001393352 NM_001393353 NM_001393354	NM_001081298
RefSeq (bjelančevina)	NP_001284633 NP_001284634 NP_001284635 NP_001317574 NP_036434 NP_001337627 NP_001337628 NP_001352931 NP_001352932 NP_001352933 NP_001352934 NP_001352935 NP_001352936 NP_001352937 NP_001352938	NP_001074767 NP_001392915 NP_001392916 NP_001392917 NP_001392918 NP_001392919 NP_001392920 NP_001392921 NP_001392922 NP_001392923 NP_001392924 NP_001392925 NP_001392926 NP_001392927 NP_001392928 NP_001392929 NP_001392930 NP_001392931 NP_001392932 NP_001392933 NP_001392934 NP_001392935 NP_001392936 NP_001392937 NP_001392938 NP_001392939 NP_001392940 NP_001392947 NP_001392948
Lokacija (UCSC)	Chr 1: 81.31 – 81.99 Mb	Chr 3: 148.82 – 148.99 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.459 aminokiselina, a molekulska težina 163.349 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MVSSGCRMRS		LWFIIVISFL		PNTEGFSRAA		LPFGLVRREL		SCEGYSIDLR
CPGSDVIMIE		SANYGRTDDK		ICDADPFQME		NTDCYLPDAF		KIMTQRCNNR
TQCIVVTGSD		VFPDPCPGTY		KYLEVQYECV		PYIFVCPGTL		KAIVDSPCIY
EAEQKAGAWC		KDPLQAADKI		YFMPWTPYRT		DTLIEYASLE		DFQNSRQTTT
YKLPNRVDGT		GFVVYDGAVF		FNKERTRNIV		KFDLRTRIKS		GEAIINYANY
HDTSPYRWGG		KTDIDLAVDE		NGLWVIYATE		QNNGMIVISQ		LNPYTLRFEA
TWETVYDKRA		ASNAFMICGV		LYVVRSVYQD		NESETGKNSI		DYIYNTRLNR
GEYVDVPFPN		QYQYIAAVDY		NPRDNQLYVW		NNNFILRYSL		EFGPPDPAQV
PTTAVTITSS		AELFKTIIST		TSTTSQKGPM		STTVAGSQEG		SKGTKPPPAV
STTKIPPITN		IFPLPERFCE		ALDSKGIKWP		QTQRGMMVER		PCPKGTRGTA
SYLCMISTGT		WNPKGPDLSN		CTSHWVNQLA		QKIRSGENAA		SLANELAKHT
KGPVFAGDVS		SSVRLMEQLV		DILDAQLQEL		KPSEKDSAGR		SYNKLQKREK
TCRAYLKAIV		DTVDNLLRPE		ALESWKHMNS		SEQAHTATML		LDTLEEGAFV
LADNLLEPTR		VSMPTENIVL		EVAVLSTEGQ		IQDFKFPLGI		KGAGSSIQLS
ANTVKQNSRN		GLAKLVFIIY		RSLGQFLSTE		NATIKLGADF		IGRNSTIAVN
SHVISVSINK		ESSRVYLTDP		VLFTLPHIDP		DNYFNANCSF		WNYSERTMMG
YWSTQGCKLV		DTNKTRTTCA		CSHLTNFAIL		MAHREIAYKD		GVHELLLTVI
TWVGIVISLV		CLAICIFTFC		FFRGLQSDRN		TIHKNLCINL		FIAEFIFLIG
IDKTKYAIAC		PIFAGLLHFF		FLAAFAWMCL		EGVQLYLMLV		EVFESEYSRK
KYYYVAGYLF		PATVVGVSAA		IDYKSYGTEK		ACWLHVDNYF		IWSFIGPVTF
IILLNIIFLV		ITLCKMVKHS		NTLKPDSSRL		ENIKSWVLGA		FALLCLLGLT
WSFGLLFINE		ETIVMAYLFT		IFNAFQGVFI		FIFHCALQKK		VRKEYGKCFR
HSYCCGGLPT		ESPHSSVKAS		TTRTSARYSS		GTQSRIRRMW		NDTVRKQSES
SFISGDINST		STLNQGMTGN		YLLTNPLLRP		HGTNNPYNTL		LAETVVCNAP
SAPVFNSPGH		SLNNARDTSA		MDTLPLNGNF		NNSYSLHKGD		YNDSVQVVDC
GLSLNDTAFE		KMIISELVHN		NLRGSSKTHN		LELTLPVKPV		IGGSSSEDDA
IVADASSLMH		SDNPGLELHH		KELEAPLIPQ		RTHSLLYQPQ		KKVKSEGTDS
YVSQLTAEAE		DHLQSPNRDS		LYTSMPNLRD		SPYPESSPDM		EEDLSPSRRS
ENEDIYYKSM		PNLGAGHQLQ		MCYQISRGNS		DGYIIPINKE		GCIPEGDVRE
GQMQLVTSL

Funkcija

Ovaj gen kodira člana potporodice latrofilinskih receptora vezanih za G-protein (GPCR). Latrofilini mogu funkcionirati i u ćelijskoj adheziji i u prijenosu signala. U eksperimentima s neljudskim vrstama, endogeno proteolitsko cijepanje unutar cisteinom bogatog GPS domena (mjesto proteolize G-protein spregnutog receptora) rezultiralo je u dvije podjedinice (velika vanćelijska N-terminal podjedinica ćelijske adhezije i podjedinica sa značajnom sličnošću sa porodica sekretin/kalcitonin GPCR-a) koji su nekovalentno vezani na ćelijskoj membrani. Iako je opisano nekoliko varijanti transkripta, utvrđena je biološka valjanost samo jedne.

Također pogledajte

• Adhezijski G-proteini spregnuti receptori

Dopunska literatura

• Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
• Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• White GR, Varley JM, Heighway J (Dec 1998). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer". Oncogene. 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
• Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007. PMID 17456239.

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.