ACSBG1

ACSBG1
Identifikatori
Aliasi	ACSBG1
Vanjski ID-jevi	OMIM: 614362 MGI: 2385656 HomoloGene: 9044 GeneCards: ACSBG1
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	78,245,688 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	54,569,154 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • ligase activity; • catalytic activity; • ATP binding; • decanoate-CoA ligase activity; • long-chain fatty acid-CoA ligase activity; • very long-chain fatty acid-CoA ligase activity;
Ćelijska komponenta	• citosol; • intracellular membrane-bounded organelle; • Endoplazmatski retikulum; • GO:0016023 citoplazmatska vezikula; • citoplazma;
Biološki proces	• lipid metabolism; • very long-chain fatty acid metabolic process; • response to glucocorticoid; • fatty acid metabolic process; • long-chain fatty-acyl-CoA biosynthetic process; • myelination; • metabolizam; • long-chain fatty acid metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	23205
	94180
	ENSG00000103740
	ENSMUSG00000032281
	Q96GR2
	Q99PU5
	NM_001199377; NM_015162
	NM_053178
	NP_001186306; NP_055977
	NP_444408
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 1 rastegljivih acil-CoA sintetaza (ACSBG1) je enzim koji je kod ljudi kodiran genom ACSBG1.^[5]^[6]^[7]

Watkins et al. (2007) odredili su da gen ACSBG1 ima 14 egzon Putem radijacijske hibridbe analize, Ishikawa et al. (1998) mapirali su ACSBG1 na hromosomu 15. Watkins et al. (2007) odredili su bližu lpkaciju ACSBG1 na minus lancu of hhromosoma15, sekvenca q23-q24.^[8]^[9]

Protein kodiran ovim genom ima dugolančanu acil-CoA sintaznu aktivnost. Smatra se da ima središnju ulogu u mozgu vrlo dugolančanim masnim kiselinama metabolizmu i mijelinogenezi.^[7] Konverziju dugih lanaca masnih kiselina u dugolančane acil-CoA, kod miševa katalizira ACSBG1.^[10]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 724 aminokiseline, a molekulska težina 81.290 Da.^[11].

10	20	30	40	50
MPRNSGAGYG	CPHGDPSMLD	SRETPQESRQ	DMIVRTTQEK	LKTSSLTDRQ
PLSKESLNHA	LELSVPEKVN	NAQWDAPEEA	LWTTRADGRV	RLRIDPSCPQ
LPYTVHRMFY	EALDKYGDLI	ALGFKRQDKW	EHISYSQYYL	LARRAAKGFL
KLGLKQAHSV	AILGFNSPEW	FFSAVGTVFA	GGIVTGIYTT	SSPEACQYIA
YDCCANVIMV	DTQKQLEKIL	KIWKQLPHLK	AVVIYKEPPP	NKMANVYTME
EFMELGNEVP	EEALDAIIDT	QQPNQCCVLV	YTSGTTGNPK	GVMLSQDNIT
WTARYGSQAG	DIRPAEVQQE	VVVSYLPLSH	IAAQIYDLWT	GIQWGAQVCF
AEPDALKGSL	VNTLREVEPT	SHMGVPRVWE	KIMERIQEVA	AQSGFIRRKM
LLWAMSVTLE	QNLTCPGSDL	KPFTTRLADY	LVLAKVRQAL	GFAKCQKNFY
GAAPMMAETQ	HFFLGLNIRL	YAGYGLSETS	GPHFMSSPYN	YRLYSSGKLV
PGCRVKLVNQ	DAEGIGEICL	WGRTIFMGYL	NMEDKTCEAI	DEEGWLHTGD
AGRLDADGFL	YITGRLKELI	ITAGGENVPP	VPIEEAVKME	LPIISNAMLI
GDQRKFLSML	LTLKCTLDPD	TSDQTDNLTE	QAMEFCQRVG	SRATTVSEII
EKKDEAVYQA	IEEGIRRVNM	NAAARPYHIQ	KWAILERDFS	ISGGELGPTM
KLKRLTVLEK	YKGIIDSFYQ	EQKM

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103740 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032281 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA (Nov 2000). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem. 275 (45): 35162–9. doi:10.1074/jbc.M006403200. PMID 10954726.
^ ^a ^b "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1".
^ Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998. PubMed: 9734811
^ Watkins, P. A., Maiguel, D., Jia, Z., Pevsner, J. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J. Lipid Res. 48: 2736-2750, 2007. PubMed: 17762044
^ Moriya-Sato A, et al. (Dec 2000). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem Biophys Res Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.
^ "UniProt, Q96GR2". Pristupljeno 12. 7. 2021.

Dopunska literatura

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Moriya-Sato A, Hida A, Inagawa-Ogashiwa M, et al. (2001). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem. Biophys. Res. Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pei Z, Oey NA, Zuidervaart MM, et al. (2004). "The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation." J. Biol. Chem. 278 (47): 47070–8. doi:10.1074/jbc.M310075200. PMID 12975357.
Fraisl P, Forss-Petter S, Zigman M, Berger J (2004). "Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase". Biochem. J. 377 (Pt 1): 85–93. doi:10.1042/BJ20031062. PMC 1223850. PMID 14516277.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Asheuer M, Bieche I, Laurendeau I, et al. (2005). "Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy". Hum. Mol. Genet. 14 (10): 1293–303. doi:10.1093/hmg/ddi140. PMID 15800013.

Vanjski linkovi

Lokacija ljudskog genoma ACSBG1 i stranica sa detaljima o genu ACSBG1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103740 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032281 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid10954726-6] Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA (Nov 2000). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem. 275 (45): 35162–9. doi:10.1074/jbc.M006403200. PMID 10954726.

[entrez-7] "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1".

[8] Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998. PubMed: 9734811

[9] Watkins, P. A., Maiguel, D., Jia, Z., Pevsner, J. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J. Lipid Res. 48: 2736-2750, 2007. PubMed: 17762044

[10] Moriya-Sato A, et al. (Dec 2000). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem Biophys Res Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.

[UniProt-11] "UniProt, Q96GR2". Pristupljeno 12. 7. 2021.

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