ZNF83

Protein 83 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF83.

ZNF83
Identifikatori
Aliasi	ZNF83
Vanjski ID-jevi	OMIM: 194558 HomoloGene: 139847 GeneCards: ZNF83
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.41 Početak 52,594,060 bp Kraj 52,690,504 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro • intracellular anatomical structure Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	55769	n/a
Ensembl	ENSG00000167766	n/a
UniProt	P51522	n/a
RefSeq (mRNK)	NM_001105549 NM_001105550 NM_001105551 NM_001105552 NM_001105553 NM_001105554 NM_001242531 NM_001242538 NM_001277945 NM_001277946 NM_001277947 NM_001277948 NM_001277949 NM_001277951 NM_001277952 NM_018300 NM_001348015 NM_001348016 NM_001348017 NM_001348018 NM_001348019	n/a
RefSeq (bjelančevina)	NP_001099019 NP_001099020 NP_001099021 NP_001099022 NP_001264874 NP_001264875 NP_001264876 NP_001264877 NP_001264878 NP_001264880 NP_001264881 NP_060770 NP_001334944 NP_001334945 NP_001334946 NP_001334947 NP_001334948	n/a
Lokacija (UCSC)	Chr 19: 52.59 – 52.69 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MHGRKDDAQK		QPVKNQLGLN		PQSHLPELQL		FQAEGKIYKY		DHMEKSVNSS
SLVSPPQRIS		STVKTHISHT		YECNFVDSLF		TQKEKANIGT		EHYKCSERGK
AFHQGLHFTI		HQIIHTKETQ		FKCDICGKIF		NKKSNLASHQ		RIHTGEKPYK
CNECGKVFHN		MSHLAQHRRI		HTGEKPYKCN		ECGKVFNQIS		HLAQHQRIHT
GEKPYKCNEC		GKVFHQISHL		AQHRTIHTGE		KPYECNKCGK		VFSRNSYLVQ
HLIIHTGEKP		YRCNVCGKVF		HHISHLAQHQ		RIHTGEKPYK		CNECGKVFSH
KSSLVNHWRI		HTGEKPYKCN		ECGKVFSHKS		SLVNHWRIHT		GEKPYKCNEC
GKVFSRNSYL		AQHLIIHAGE		KPYKCDECDK		AFSQNSHLVQ		HHRIHTGEKP
YKCDECGKVF		SQNSYLAYHW		RIHTGEKAYK		CNECGKVFGL		NSSLAHHRKI
HTGEKPFKCN		ECGKAFSMRS		SLTNHHAIHT		GEKHFKCNEC		GKLFRDNSYL
VRHQRFHAGK		KSNTCN

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.

Dopunska literatura

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Abrink M, Aveskogh M, Hellman L (1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
• Bellefroid EJ, Lecocq PJ, Benhida A, et al. (1989). "The human genome contains hundreds of genes coding for finger proteins of the Krüppel type". DNA. 8 (6): 377–87. doi:10.1089/dna.1.1989.8.377. PMID 2505992.