ZNF541

Protein 541 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF536.

ZNF541
Identifikatori
Aliasi	ZNF541
Vanjski ID-jevi	MGI: 3647699 HomoloGene: 12991 GeneCards: ZNF541
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.33 Početak 47,520,690 bp Kraj 47,573,148 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 A2 Početak 15,795,739 bp Kraj 15,830,259 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • transcription regulator complex • jedro • histone deacetylase complex Biološki proces • multicellular organism development • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • Spermatogeneza • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	84215	666528
Ensembl	ENSG00000118156	ENSMUSG00000078796
UniProt	Q9H0D2	Q0GGX2
RefSeq (mRNK)	NM_001101419 NM_001277075 NM_032255	NM_001099277 NM_001347559
RefSeq (bjelančevina)	NP_001264004	NP_001092747 NP_001334488
Lokacija (UCSC)	Chr 19: 47.52 – 47.57 Mb	Chr 7: 15.8 – 15.83 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MDQYSLGDEG		ALPSEMHLPS		FSESQGLNCS		DTLNRDLGPN		TRGFLYAGLS
GLDPDPSLPT		PDMSSEVLED		NLDTLSLYSG		KDSDSVKLLE		EYADSESQAS
LQDLGLGVLK		AKEADEGGRA		TSGSARKGKR		QHSSPQNPLL		DCSLCGKVFS
SASSLSKHYL		THSQERKHVC		KICSKAFKRQ		DHLTGHMLTH		QKTKPFVCIE
QGCSKSYCDY		RSLRRHYEVH		HGLCILKEAP		PEEEACGDSP		HAHESAGQPP
PSSLRSLVPP		EARSPGSLLP		HRDLLRRIVS		SIVHQKTPSP		GPAPAGASDS
EGRNTACPCP		ASSGSSSCTP		AGPHAAPAAL		DTELPEEPCL		PQKEPATDVF
TAPNSRAAEN		GAPDPPEPEP		DTALLQARST		AECWPEGGSV		PACLPLFRGQ
TVPASSQPSS		HSFQWLRNLP		GCPKSKGNNV		FVVHKPSAVP		SREGSESGPG
PSSGSPSEES		PPGPGGGLED		ALPFPAALLR		VPAEAPSDPR		SASGEDDPCA
PKKVKVDCDS		FLCQNPGEPG		LQEAQKAGGL		PADASPLFRQ		LFLKSQEPLV
SHEQMQVFQM		ITKSQRIFSH		AQVAAVSSQL		PAPEGKPAAL		RPLQGPWPQQ
PPPLAPAVDS		LHAGPGNPEA		EGSPARRRKT		TPGVPREASP		GSTRRDAKGG
LKVAAVPTPL		AAPSLDPSRN		PDISSLAKQL		RSSKGTLDLE		DIFPSTGQRQ
TQLGGEEPPG		ASLPGKQAPA		ENGAASRITK		GEKGPACSRG		GGYRLLGNPR
APRFSGFRKE		KAKMDMCCAA		SPSQVAMASF		SSAGPPADPS		KSKLTIFSRI
QGGNIYRLPH		PVKEENVAGR		GNQQNGSPTD		WTKPRSTFVC		KNCSQMFYTE
KGLSSHMCFH		SDQWPSPRGK		QEPQVFGTEF		CKPLRQVLRP		EGDRHSPPGT
KKPLDPTAAA		PLVVPQSIPV		VPVTRHIGSM		AMGQEKDGEE		RDSKESSQQR
KRKKRPPPST		AGEPGPAGCH		QSRLRSPMFL		VDCLLKGLFQ		CSPYTPPPML
SPIREGSGVY		FNTLCSTSTQ		ASPDQLISSM		LDQVDGSFGI		CVVKDDTKIS
IEPHINIGSR		FQAEIPELQE		RSLAGTDEHV		ASLVWKPWGD		MMISSETQDR
VTELCNVACS		SVMPGGGTNL		ELALHCLHEA		QGNVQVALET		LLLRGPHKPR
THLLADYRYT		GSDVWTPIEK		RLFKKAFYAH		KKDFYLIHKM		IQTKTVAQCV
EYYYIWKKMI		KFDCGRAPGL		EKRVKREPEE		VERTEEKVPC		SPRERPSHHP
TPKLKTKSYR		RESILSSSPN		AGSKRTPELL		GSAESQGIFP		CRECERVFDK
IKSRNAHMKR		HRLQDHVEPI		IRVKWPVKPF		QLKEEELGAD		IGPLQW

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.