ZNF536

Protein 536 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF536.

ZNF536
Identifikatori
Aliasi	ZNF536
Vanjski ID-jevi	OMIM: 618037 MGI: 1926102 HomoloGene: 8813 GeneCards: ZNF536
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q12 Početak 30,228,290 bp Kraj 30,713,538 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 B2-B3 Početak 37,318,024 bp Kraj 37,773,641 bp
Ontologija gena Molekularna funkcija • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • vezivanje sa DNK • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • retinoic acid-responsive element binding • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro Biološki proces • negative regulation of retinoic acid receptor signaling pathway • multicellular organism development • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of neuron differentiation • GO:0072468 Transdukcija signala • transcription, DNA-templated Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9745	243937
Ensembl	ENSG00000198597	ENSMUSG00000043456
UniProt	O15090	Q8K083
RefSeq (mRNK)	NM_014717 NM_001352260 NM_001376110 NM_001376111	NM_172385
RefSeq (bjelančevina)	NP_055532 NP_001339189 NP_001363039 NP_001363040	NP_759017 NP_001391020 NP_001391022 NP_001391023 NP_001391024 NP_001391025 NP_001391026 NP_001391028 NP_001391029
Lokacija (UCSC)	Chr 19: 30.23 – 30.71 Mb	Chr 7: 37.32 – 37.77 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MEEASLCLGV		SSAEPEAEPH		LSGPVLNGQY		AMSQKLHQIT		SQLSHAFPEL
HPRPNPEEKP		PASLEEKAHV		PMSGQPMGSQ		MALLANQLGR		EVDTSLNGRV
DLQQFLNGQN		LGIMSQMSDI		EDDARKNRKY		PCPLCGKRFR		FNSILSLHMR
THTGEKPFKC		PYCDHRAAQK		GNLKIHLRTH		KLGNLGKGRG		RVREENRLLH
ELEERAILRD		KQLKGSLLQP		RPDLKPPPHA		QQAPLAACTL		ALQANHSVPD
VAHPVPSPKP		ASVQEDAVAP		AAGFRCTFCK		GKFKKREELD		RHIRILHKPY
KCTLCDFAAS		QEEELISHVE		KAHITAESAQ		GQGPNGGGEQ		SANEFRCEVC
GQVFSQAWFL		KGHMRKHKDS		FEHCCQICGR		RFKEPWFLKN		HMKVHLNKLS
VKNKSPSDPE		VPVPMGGMSQ		EAHANLYSRY		LSCLQSGFMT		PDKAGLSEPS
QLYGKGELPM		KEKEALGKLL		SPISSMAHGV		PEGDKHSLLG		CLNLVPPLKS
SCIERLQAAA		KAAEMDPVNS		YQAWQLMARG		MAMEHGFLSK		EHPLQRNHED
TLANAGVLFD		KEKREYVLVG		ADGSKQKMPA		DLVHSTKVGS		QRDLPSKLDP
LESSRDFLSH		GLNQTLEYNL		QGPGNMKEKP		TECPDCGRVF		RTYHQVVVHS
RVHKRDRKGE		EDGLHVGLDE		RRGSGSDQES		QSVSRSTTPG		SSNVTEESGV
GGGLSQTGSA		QEDSPHPSSP		SSSDIGEEAG		RSAGVQQPAL		LRDRSLGSAM
KDCPYCGKTF		RTSHHLKVHL		RIHTGEKPYK		CPHCDYAGTQ		SASLKYHLER
HHRERQNGAG		PLSGQPPNQD		HKDEMSSKAS		LFIRPDILRG		AFKGLPGIDF
RGGPASQQWT		SGVLSSGDHS		GQATGMSSEV		PSDALKGTDL		PSKSTHFSEI
GRAYQSIVSN		GVNFQGSLQA		FMDSFVLSSL		KKEKDMKDKA		LADPPSMKVH
GVDGGEEKPS		GKSSQRKSEK		SQYEPLDLSV		RPDAASLPGS		SVTVQDSIAW
HGCLFCAFTT		SSMELMALHL		QANHLGKAKR		KDNTIGVTVN		CKDQAREASK
MALLPSLQSN		KDLGLSNMIS		SLDSASEKMA		QGQLKETLGE		QKSGAWTGHV
DPAFCNFPSD		FYKQFGVYPG		MVGSGASSSC		PNKEPDGKAH		SEEDVPILIP
ETTSKNTTDD		LSDIASSEDM		DSSKGENNDE		EDVETEPEMM		TKPLSALSKD
SSSDGGDSLQ		PTGTSQPVQG		LVSPLSQAPE		KQWHSQGLLQ		AQDPLAGLPK
PERGPQSLDK		PMNMLSVLRA		YSSDGLAAFN		GLASSTANSG		CIKRPDLCGK

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.

Dopunska literatura

• Qin Z, Ren F, Xu X, Ren Y, Li H, Wang Y, Zhai Y, Chang Z (juli 2009). "ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription". Molecular and Cellular Biology. 29 (13): 3633–43. doi:10.1128/MCB.00362-09. PMC 2698762. PMID 19398580.
• Dugas JC, Tai YC, Speed TP, Ngai J, Barres BA (oktobar 2006). "Functional genomic analysis of oligodendrocyte differentiation". The Journal of Neuroscience. 26 (43): 10967–83. doi:10.1523/JNEUROSCI.2572-06.2006. PMC 6674672. PMID 17065439.
• Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, Govindaraju DR, Kathiresan S, Keaney JF, Keyes MJ, Lin JP, Meigs JB, Robins SJ, Rong J, Schnabel R, Vita JA, Wang TJ, Wilson PW, Wolf PA, Vasan RS (septembar 2007). "Genome-wide association with select biomarker traits in the Framingham Heart Study". BMC Medical Genetics. 8 Suppl 1: S11. doi:10.1186/1471-2350-8-S1-S11. PMC 1995615. PMID 17903293.
• Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M, Nakamura Y (august 2013). "Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan". Cancer Science. 104 (8): 1074–82. doi:10.1111/cas.12186. PMC 7657179. PMID 23648065. S2CID 5954226.
• Meng W, Butterworth J, Bradley DT, Hughes AE, Soler V, Calvas P, Malecaze F (decembar 2012). "A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population". Investigative Ophthalmology & Visual Science. 53 (13): 7983–8. doi:10.1167/iovs.12-10409. PMID 23049088.
• Sakai T, Hino K, Wada S, Maeda H (august 2003). "Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor". DNA Research. 10 (4): 155–65. doi:10.1093/dnares/10.4.155. PMID 14621294.
• Seppälä I, Kleber ME, Lyytikäinen LP, Hernesniemi JA, Mäkelä KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kähönen N, Alfthan G, Viikari JS, Kähonen M, Raitakari OT, März W, Meinitzer A, Lehtimäki T (februar 2014). "Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality". European Heart Journal. 35 (8): 524–31. doi:10.1093/eurheartj/eht447. PMID 24159190.