ZNF331
Protein 331 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF331.[3]
- Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAQGLVTFAD | VAIDFSQEEW | ACLNSAQRDL | YWDVMLENYS | NLVSLDLESA | ||||
| YENKSLPTEK | NIHEIRASKR | NSDRRSKSLG | RNWICEGTLE | RPQRSRGRYV | ||||
| NQMIINYVKR | PATREGTPPR | THQRHHKENS | FECKDCGKAF | SRGYQLSQHQ | ||||
| KIHTGEKPYE | CKECKKAFRW | GNQLTQHQKI | HTGEKPYECK | DCGKAFRWGS | ||||
| SLVIHKRIHT | GEKPYECKDC | GKAFRRGDEL | TQHQRFHTGE | KDYECKDCGK | ||||
| TFSRVYKLIQ | HKRIHSGEKP | YECKDCGKAF | ICGSSLIQHK | RIHTGEKPYE | ||||
| CQECGKAFTR | VNYLTQHQKI | HTGEKPHECK | ECGKAFRWGS | SLVKHERIHT | ||||
| GEKPYKCTEC | GKAFNCGYHL | TQHERIHTGE | TPYKCKECGK | AFIYGSSLVK | ||||
| HERIHTGVKP | YGCTECGKSF | SHGHQLTQHQ | KTHSGAKSYE | CKECGKACNH | ||||
| LNHLREHQRI | HNS |
Interakcije
urediPokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju. Pogledajte ZFP93 (MIM 604749) za dodatne informacije o proteinima cinkovih prstiju, prema OMIM-u.[3]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000130844 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ZNF331 zinc finger protein 331".
Dopunska literatura
uredi- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Meiboom M, Murua Escobar H, Winkler S, et al. (2004). "Molecular characterization and mapping of the canine KRAB zinc finger gene ZNF331". Anim. Genet. 35 (3): 262–3. doi:10.1111/j.1365-2052.2004.01146.x. PMID 15147412.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Meiboom M, Murua Escobar H, Pentimalli F, et al. (2003). "A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas". Cytogenet. Genome Res. 101 (2): 113–7. doi:10.1159/000074165. PMID 14610350. S2CID 22276378.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wu H, Zhang S, Qiu W, et al. (2001). "Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463". Biochim. Biophys. Acta. 1518 (1–2): 190–3. doi:10.1016/s0167-4781(01)00172-5. PMID 11267678.
- Rippe V, Belge G, Meiboom M, et al. (2000). "A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors". Genes Chromosomes Cancer. 26 (3): 229–36. doi:10.1002/(SICI)1098-2264(199911)26:3<229::AID-GCC7>3.0.CO;2-J. PMID 10502321.