ZNF224

ZNF224
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	2ELY, 2ELZ, 2EM0, 2EM6, 2EM7, 2EM8, 2EM9, 2EN1, 2EN8, 2ENA, 2ENC, 2EOQ, 2EOR, 2EQ4, 2YSP, 2YTH
Identifikatori
Aliasi	ZNF224
Vanjski ID-jevi	OMIM: 194555 HomoloGene: 130663 GeneCards: ZNF224
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	44,109,886 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje iona metala; • vezivanje sa DNK; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • intracellular anatomical structure; • Jedarna membrana; • transcription repressor complex;
Biološki proces	• GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	7767
	n/a
	ENSG00000267680
	n/a
	Q9NZL3
	n/a
	NM_013398; NM_001321645
	n/a
	NP_001308574; NP_037530
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Protein 224 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF224.^[3]

Aminokiselinski sastav

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MTTFKEAMTF	KDVAVVFTEE	ELGLLDLAQR	KLYRDVMLEN	FRNLLSVGHQ
AFHRDTFHFL	REEKIWMMKT	AIQREGNSGD	KIQTEMETVS	EAGTHQEWSF
QQIWEKIASD	LTRSQDLMIN	SSQFSKEGDF	PCQTEAGLSV	IHTRQKSSQG
NGYKPSFSDV	SHFDFHQQLH	SGEKSHTCDE	CGKNFCYISA	LRIHQRVHMG
EKCYKCDVCG	KEFSQSSHLQ	THQRVHTGEK	PFKCVECGKG	FSRRSALNVH
HKLHTGEKPY	NCEECGKAFI	HDSQLQEHQR	IHTGEKPFKC	DICGKSFCGR
SRLNRHSMVH	TAEKPFRCDT	CDKSFRQRSA	LNSHRMIHTG	EKPYKCEECG
KGFICRRDLY	THHMVHTGEK	PYNCKECGKS	FRWASCLLKH	QRVHSGEKPF
KCEECGKGFY	TNSQCYSHQR	SHSGEKPYKC	VECGKGYKRR	LDLDFHQRVH
TGEKLYNCKE	CGKSFSRAPC	LLKHERLHSG	EKPFQCEECG	KRFTQNSHLH
SHQRVHTGEK	PYKCEKCGKG	YNSKFNLDMH	QKVHTGERPY	NCKECGKSFG
WASCLLKHQR	LHSGEKPFKC	EECGKRFTQN	SQLHSHQRVH	TGEKPYKCDE
CGKGFSWSST	RLTHQRRHSR	ETPLKCEQHG	KNIVQNSFSK	VQEKVHSVEK
PYKCEDCGKG	YNRRLNLDMH	QRVHMGEKTW	KCRECDMCFS	QASSLRLHQN
VHVGEKP

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000267680 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ZNF224 zinc finger protein 224".

Dopunska literatura

Medugno L, Florio F, Cesaro E, et al. (2007). "Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Krüppel-like zinc-finger protein family". Gene. 403 (1–2): 125–131. doi:10.1016/j.gene.2007.07.036. PMID 17900823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Shannon M, Hamilton AT, Gordon L, et al. (2003). "Differential Expansion of Zinc-Finger Transcription Factor Loci in Homologous Human and Mouse Gene Clusters". Genome Res. 13 (6A): 1097–1110. doi:10.1101/gr.963903. PMC 403638. PMID 12743021.
Medugno L, Costanzo P, Lupo A, et al. (2004). "A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression". FEBS Lett. 534 (1–3): 93–100. doi:10.1016/S0014-5793(02)03783-3. PMID 12527367. S2CID 3087490.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee TH, Lwu S, Kim J, Pelletier J (2003). "Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor". J. Biol. Chem. 277 (47): 44826–44837. doi:10.1074/jbc.M205667200. PMID 12239212.
Han ZG, Zhang QH, Ye M, et al. (2000). "Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB". J. Biol. Chem. 274 (50): 35741–35748. doi:10.1074/jbc.274.50.35741. PMID 10585455.
Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–374. PMID 2288909.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000267680 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: ZNF224 zinc finger protein 224".

[3]

[1]

[2]