ZFP161

Proteinski homolog 161 cinkovog prsta je protein koji je kod ljudi kodiran genom ZFP161.

ZFP161
Identifikatori
Aliasi	ZBTB14
Vanjski ID-jevi	OMIM: 602126 MGI: 1195345 HomoloGene: 2560 GeneCards: ZBTB14
Lokacija gena (čovjek) Hrom. Hromosom 18 (čovjek) Bend 18p11.31 Početak 5,289,019 bp Kraj 5,297,053 bp
Lokacija gena (miš) Hrom. Hromosom 17 (miš) Bend 17 E1.3|17 40.42 cM Početak 69,690,045 bp Kraj 69,698,194 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro • nukleoplazma • Jedarce • citosol • aggresome Biološki proces • cardiac septum development • heart valve development • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • coronary vasculature development • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7541	22666
Ensembl	ENSG00000198081	ENSMUSG00000049672
UniProt	O43829	Q08376
RefSeq (mRNK)	NM_003409 NM_001143823 NM_001243702 NM_001243704	NM_009547 NM_001356282 NM_001356283
RefSeq (bjelančevina)	NP_001137295 NP_001230631 NP_001230633 NP_003400	NP_033573 NP_001343211 NP_001343212
Lokacija (UCSC)	Chr 18: 5.29 – 5.3 Mb	Chr 17: 69.69 – 69.7 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 449 aminokiselina, sa molekulskom težinom od 50.956..

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MEFFISMSET		IKYNDDDHKT		LFLKTLNEQR		LEGEFCDIAI		VVEDVKFRAH
RCVLAACSTY		FKKLFKKLEV		DSSSVIEIDF		LRSDIFEEVL		NYMYTAKISV
KKEDVNLMMS		SGQILGIRFL		DKLCSQKRDV		SSPDENNGQS		KSKYCLKINR
PIGDAADTQD		DDVEEIGDQD		DSPSDDTVEG		TPPSQEDGKS		PTTTLRVQEA
ILKELGSEEV		RKVNCYGQEV		ESMETPESKD		LGSQTPQALT		FNDGMSEVKD
EQTPGWTTAA		SDMKFEYLLY		GHHREQIACQ		ACGKTFSDEG		RLRKHEKLHT
ADRPFVCEMC		TKGFTTQAHL		KEHLKIHTGY		KPYSCEVCGK		SFIRAPDLKK
HERVHSNERP		FACHMCDKAF		KHKSHLKDHE		RRHRGEKPFV		CGSCTKAFAK
ASDLKRHENN		MHSERKQVTP		SAIQSETEQL		QAAAMAAEAE		QQLETIACS

Također pogledajte

• Hromosom 18
• Homologija sekvence
• Cinkov prst

Dopunska literatura

• Numoto M, Niwa O, Kaplan J, et al. (1993). "Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins". Nucleic Acids Res. 21 (16): 3767–75. doi:10.1093/nar/21.16.3767. PMC 309887. PMID 8367294.
• Sugiura K; Muro Y; Nagai Y; et al. (1997). "Expression cloning and intracellular localization of a human ZF5 homologue". Biochim. Biophys. Acta. 1352 (1): 23–6. doi:10.1016/s0167-4781(97)00045-. PMID 9177479.
• Obata T; Yanagidani A; Yokoro K; et al. (1999). "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5". Biochem. Biophys. Res. Commun. 255 (2): 528–34. doi:10.1006/bbrc.1998.9970. PMID 10049742.
• Numoto M, Yokoro K, Koshi J (1999). "ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association". Biochem. Biophys. Res. Commun. 256 (3): 573–8. doi:10.1006/bbrc.1999.0375. PMID 10080939.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lee KH, Kwak YD, Kim DH, et al. (2004). "Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter". Biochem. Biophys. Res. Commun. 313 (4): 969–76. doi:10.1016/j.bbrc.2003.11.183. PMID 14706637.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang J, Kudoh J, Takayanagi A, Shimizu N (2005). "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochem. Biophys. Res. Commun. 327 (2): 615–27. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
• Orlov SV, Kuteĭkin-Tepliakov KB, Grishin AV, et al. (2006). "[Transcription factor ZF5 regulates expression of mammalian gene containing GCC-triplet repeats in 5'-regulatory region in human hepatoma HepG2 cells]". Tsitologiia. 48 (3): 246–52. PMID 16805315.
• Orlov SV, Kuteykin-Teplyakov KB, Ignatovich IA, et al. (2007). "Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5". FEBS J. 274 (18): 4848–62. doi:10.1111/j.1742-4658.2007.06006.x. PMID 17714511. S2CID 31019370.