NEF3

NEF3
Identifikatori
Aliasi	YTHDF3
Vanjski ID-jevi	MGI: 1918850 HomoloGene: 34991 GeneCards: YTHDF3
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	63,212,786 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	16,271,201 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • N6-methyladenosine-containing RNA binding; • vezivanje sa RNK; • ribosome binding;
Ćelijska komponenta	• citoplazma; • citosol;
Biološki proces	• positive regulation of translation; • positive regulation of translational initiation; • mRNA destabilization;
	Izvori:Amigo / QuickGO
Ortolozi
	253943
	229096
	ENSG00000185728
	ENSMUSG00000047213
	Q7Z739
	Q8BYK6
NM_001277813; NM_001277814; NM_001277815; NM_001277816; NM_001277817;
	NM_001277818; NM_152758
	NM_001145919; NM_172677; NM_001358041; NM_001358042; NM_001358043
NP_001264742; NP_001264743; NP_001264744; NP_001264745; NP_001264746;
	NP_001264747; NP_689971
	NP_001139391; NP_766265; NP_001344970; NP_001344971; NP_001344972
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein porodice sa domenom 3YTH je protein koji je kod ljudi kodiran genom YTHDF3.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 585 aminokiselina, а molekulska težina 63.861 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSATSVDQRP	KGQGNKVSVQ	NGSIHQKDAV	NDDDFEPYLS	SQTNQSNSYP
PMSDPYMPSY	YAPSIGFPYS	LGEAAWSTAG	DQPMPYLTTY	GQMSNGEHHY
IPDGVFSQPG	ALGNTPPFLG	QHGFNFFPGN	ADFSTWGTSG	SQGQSTQSSA
YSSSYGYPPS	SLGRAITDGQ	AGFGNDTLSK	VPGISSIEQG	MTGLKIGGDL
TAAVTKTVGT	ALSSSGMTSI	ATNSVPPVSS	AAPKPTSWAA	IARKPAKPQP
KLKPKGNVGI	GGSAVPPPPI	KHNMNIGTWD	EKGSVVKAPP	TQPVLPPQTI
IQQPQPLIQP	PPLVQSQLPQ	QQPQPPQPQQ	QQGPQPQAQP	HQVQPQQQQL
QNRWVAPRNR	GAGFNQNNGA	GSENFGLGVV	PVSASPSSVE	VHPVLEKLKA
INNYNPKDFD	WNLKNGRVFI	IKSYSEDDIH	RSIKYSIWCS	TEHGNKRLDA
AYRSLNGKGP	LYLLFSVNGS	GHFCGVAEMK	SVVDYNAYAG	VWSQDKWKGK
FEVKWIFVKD	VPNNQLRHIR	LENNDNKPVT	NSRDTQEVPL	EKAKQVLKII
ATFKHTTSIF	DDFAHYEKRQ	EEEEAMRRER	NRNKQ

Također pogledajte

N⁶-Methiladenozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185728 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047213 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: YTHDF3 YTH domain family, member 3".
^ "UniProt, Q7Z739" (jezik: eng). Pristupljeno 20. 9. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185728 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047213 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: YTHDF3 YTH domain family, member 3".

[UniProt-7] "UniProt, Q7Z739" (jezik: eng). Pristupljeno 20. 9. 2021.CS1 održavanje: nepoznati jezik (link)

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