WBP4

WBP4
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2DK1, 2JXW
Identifikatori
Aliasi	WBP4
Vanjski ID-jevi	OMIM: 604981 MGI: 109568 HomoloGene: 38287 GeneCards: WBP4
Lokacija gena (čovjek)
Hrom.	Hromosom 13 (čovjek)
Kraj	41,084,006 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	79,718,960 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje iona cinka; • proline-rich region binding; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • nucleic acid binding;
Ćelijska komponenta	• nuclear speck; • spliceosomal complex; • nukleoplazma; • jedro; • U2-type precatalytic spliceosome;
Biološki proces	• mRNA cis splicing, via spliceosome; • mRNA processing; • Prerada RNK; • mRNA splicing, via spliceosome;
	Izvori:Amigo / QuickGO
Ortolozi
	11193
	22380
	ENSG00000120688
	ENSMUSG00000022023
	O75554
	Q61048
	NM_007187
	NM_018765
	NP_009118
	NP_061235
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

WW domen-vezujući protein 4 je proteinkoji je kod ljudi kodiran genom WBP4.^[5]^[6]

Ovaj gen kodira domen WW, koji sadrži vezujući protein 4. WW domen predstavlja malu i kompaktnu koptastu strukturu koja stupa u interakciju s prolinom bogatim ligandima. Ovaj kodirani protein je općeniti splajsosomni protein koji može imati ulogu u unakrsnom premošćivanju U1 i U2 snRNP-ova u splajsosomnom kompleksu A.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 376 aminokiselina, a molekulska težina 42.507 Da.^[7].

10	20	30	40	50
MADYWKSQPK	KFCDYCKCWI	ADNRPSVEFH	ERGKNHKENV	AKRISEIKQK
SLDKAKEEEK	ASKEFAAMEA	AALKAYQEDL	KRLGLESEIL	EPSITPVTST
IPPTSTSNQQ	KEKKEKKKRK	KDPSKGRWVE	GITSEGYHYY	YDLISGASQW
EKPEGFQGDL	KKTAVKTVWV	EGLSEDGFTY	YYNTETGESR	WEKPDDFIPH
TSDLPSSKVN	ENSLGTLDES	KSSDSHSDSD	GEQEAEEGGV	STETEKPKIK
FKEKNKNSDG	GSDPETQKEK	SIQKQNSLGS	NEEKSKTLKK	SNPYGEWQEI
KQEVESHEEV	DLELPSTENE	YVSTSEADGG	GEPKVVFKEK	TVTSLGVMAD
GVAPVFKKRR	TENGKSRNLR	QRGDDQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120688 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022023 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
^ ^a ^b "Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)".
^ "UniProt, O75554". Pristupljeno 5. 8. 2021.

Dopunska literatura

Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site". Mol. Cell. 18 (2): 245–51. doi:10.1016/j.molcel.2005.03.018. PMID 15837427.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains". EMBO J. 15 (5): 1045–54. doi:10.1002/j.1460-2075.1996.tb00442.x. PMC 450002. PMID 8605874.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120688 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022023 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9724750-5] Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.

[entrez-6] "Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)".

[UniProt-7] "UniProt, O75554". Pristupljeno 5. 8. 2021.

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