Amiokiselininska sekvenca
uredi
Dužina polipeptidnog lanca je 269 aminokiselina , a molekulska težina Da . 29 140[ 7]
10 20 30 40 50 MARASSGNGS EEAWGALRAP QQQLRELCPG VNNQPYLCES GHCCGETGCC TYYYELWWFW LLWTVLILFS CCCAFRHRRA KLRLQQQQRQ REINLLAYHG ACHGAGPFPT GSLLDLRFLS TFKPPAYEDV VHRPGTPPPP YTVAPGRPLT ASSEQTCCSS SSSCPAHFEG TNVEGVSSHQ SAPPHQEGEP GAGVTPASTP PSCRYRRLTG DSGIELCPCP ASGEGEPVKE VRVSATLPDL EDYSPCALPP ESVPQIFPMG LSSSEGDIP
Globulasti WW domen sastoji se od 38 do 40 polukonzerviranih aminokiselina koje dijele proteini različitih funkcija uključujući strukturne, regulatorne i signalne proteine Domen je uključen u posredovanje interakcija protein-protein , putem međusobnog vezivanjs proteina. poliprolinskog liganda .
Ovaj gen kodira protein koji se vezuje za WW domen, vezan za WW domen proteina povezanog sa kinazom Yes, pomoću konzerviranopgg regiona: motiva XPPXY. Funkcija ovog proteina nije utvrđena.[ 6]
Dopunska literatura
uredi
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins" . Oncogene . 23 (29): 5049–55. doi :10.1038/sj.onc.1207680 . PMC 4143251 PMID 15064722 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4" . Biochem. J . 351 Pt 3 (3): 557–65. doi :10.1042/0264-6021:3510557 . PMC 1221394 PMID 11042109 . Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands" . J. Biol. Chem . 272 (27): 17070–7. doi :10.1074/jbc.272.27.17070 PMID 9202023 . Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets" . J. Biol. Chem . 272 (23): 14611–6. doi :10.1074/jbc.272.23.14611 PMID 9169421 . 
