WASHC2C

Podjedinica 2C kompleksa WASH jest protein koji je kod ljudi kodiran genom WASHC2C.

WASHC2C
Identifikatori
Aliasi	WASHC2C
Vanjski ID-jevi	OMIM: 613631 MGI: 106463 HomoloGene: 41686 GeneCards: WASHC2C
Lokacija gena (čovjek) Hrom. Hromosom 10 (čovjek) Bend 10q11.22 Početak 45,727,200 bp Kraj 45,792,961 bp
Lokacija gena (miš) Hrom. Hromosom 6 (miš) Bend 6 E3|6 53.76 cM Početak 116,184,999 bp Kraj 116,239,647 bp
Ontologija gena Molekularna funkcija • phosphatidylinositol-3-phosphate binding • phosphatidylinositol-3,5-bisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding • phosphatidylinositol-4-phosphate binding • phosphatidylinositol-5-phosphate binding • GO:0001948, GO:0016582 vezivanje za proteine • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-3,4,5-trisphosphate binding • lipid binding • retromer complex binding Ćelijska komponenta • early endosome membrane • intracellular membrane-bounded organelle • membrana • ćelijska membrana • retromer complex • early endosome • Jedarce • endozom • WASH complex • citosol Biološki proces • negative regulation of barbed-end actin filament capping • retrograde transport, endosome to Golgi • protein transport • regulation of substrate adhesion-dependent cell spreading • protein localization to endosome Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	253725	28006
Ensembl	ENSG00000172661	ENSMUSG00000024104
UniProt	Q9Y4E1	Q6PGL7
RefSeq (mRNK)	NM_001169106 NM_001169107 NM_015262 NM_001330074	NM_026585
RefSeq (bjelančevina)	NP_001162577 NP_001162578 NP_001317003 NP_056077 NP_001354322 NP_001354323 NP_001354324 NP_001354325 NP_001354326 NP_001354327 NP_001354328 NP_001354329 NP_001354330 NP_001354331 NP_001354332 NP_001354333 NP_001354334 NP_001354335 NP_001354336 NP_001354337 NP_001354338 NP_001354339 NP_001354340 NP_001354341 NP_001354342 NP_001354343 NP_001354344 NP_001354345	NP_080861
Lokacija (UCSC)	Chr 10: 45.73 – 45.79 Mb	Chr 6: 116.18 – 116.24 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.318 aminokiselina, a molekulska težina 144.668

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MMNRTTPDQE		LVPASEPVWE		RPWSVEEIRR		SSQSWSLAAD		AGLLQFLQEF
SQQTISRTHE		IKKQVDGLIR		ETKATDCRLH		NVFNDFLMLS		NTQFIENRVY
DEEVEEPVLK		AEAEKTEQEK		TREQKEVDLI		PKVQEAVNYG		LQVLDSAFEQ
LDIKAGNSDS		EEDDANGRVE		LILEPKDLYI		DRPLPYLIGS		KLFMEQEDVG
LGELSSEEGS		VGSDRGSIVD		TEEEKEEEES		DEDFAHHSDN		EQNQHTTQMS
DEEEDDDGCD		LFADSEKEEE		DIEDIEENTR		PKRSRPTSFA		DELAARIKGD
AMGRVDEEPT		TLPSGEAKPR		KTLKEKKERR		TPSDDEEDNL		FAPPKLTDED
FSPFGSGGGL		FSGGKGLFDD		EDEESDLFTE		ASQDRQAGAS		VKEESSSSKP
GKKIPAGAVS		VFLGDTDVFG		AASVPSLKEP		QKPEQPTPRK		SPYGPPPTGL
FDDDDGDDDD		DFFSAPHSKP		SKTRKVQSTA		DIFGDEEGDL		FKEKAVASPE
ATVSQTDENK		ARAEKKVTLS		YSKNLKPSSE		TKTQKGLFSD		EEDSEDLFSS
QSASNLKGAS		LLPGKLPTSV		SLFDDEDEED		NLFGGTAAKK		QTLSLQAQRE
EKAKASELSK		KKASALLFSS		DEEWNIPASQ		THLASDSRSK		GEPRDSGTLQ
SQEAKAVKKT		SLFEEDKEDD		LFAIAKDSQK		KTQRVSLLFE		DDVDSGGSLF
GSPPTSVPPA		TKKKETVSEA		PPLLFSDEEE		KEAQLGVKSV		DKKVESAKES
LKFGRTDVAE		SEKEGLLTRS		AQETVKHSDL		FSSSSPWDKG		TKPRTKTVLS
LFDEEEDKME		DQNIIQAPQK		EVGKGCDPDA		HPKSTGVFQD		EELLFSHKLQ
KDNDPDVDLF		AGTKKTKLLE		PSVGSLFGDD		EDDDLFSSAK		SQPLVQEKKR
VVKKDHSVNS		FKNQKHPESI		QGSKEKGIWK		PETPQANLAI		NPAALLPTAA
SQISEVKPVL		PELAFPSSEH		RRSHGLESVP		VLPGSGEAGV		SFDLPAQADT
LHSANKSRVK		MRGKRRPQTR		AARRLAAQES		SEAEDMSVPR		GPIAQWADGA
ISPNGHRPQL		RAASGEDSTE		EALAAAAAPW		EGGPVPGVDT		SPFAKSLGHS
RGEADLFDSG		DIFSTGTGSQ		SVERTKPKAK		IAENPANPPV		GGKAKSPMFP
ALGEASSDDD		LFQSAKPKPA		KKTNPFPLLE		DEDDLFTDQK		VKKNETKSSS
QQDVILTTQD		IFEDDIFATE		AIKPSQKTRE		KEKTLESNLF		DDNIDIFADL
TVKPKEKSKK		KVEAKSIFDD		DMDDIFSTGI		QAKTTKPKSR		SAQAAPEPRF
EHKVSNIFDD		PLNAFGGQ

Dopunska literatura

• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.