UPK1A

UPK1A
Identifikatori
Aliasi	UPK1A
Vanjski ID-jevi	OMIM: 611557 MGI: 98911 HomoloGene: 21383 GeneCards: UPK1A
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	35,678,481 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	30,312,272 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • integral component of plasma membrane; • Egzosom; • apical plasma membrane; • Endoplazmatski retikulum; • membrana; • cell surface; • apical plasma membrane urothelial plaque;
Biološki proces	• cell surface receptor signaling pathway; • epithelial cell differentiation; • protein complex oligomerization;
	Izvori:Amigo / QuickGO
Ortolozi
	11045
	109637
	ENSG00000105668
	ENSMUSG00000006313
	O00322
	Q9D132
	NM_007000; NM_001281443
	NM_026815
	NP_001268372; NP_008931
	NP_081091
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Uroplakin-1a je protein koji je kod ljudi kodiran genom UPK1A.^[5]^[6]^[7]

Protein koji je kodiran ovim genom član je transmembranske superporodice 4 , poznate i kao porodica tetraspanina. Većina ovih članova su proteini na ćelijskoj površini, koje karakterizira prisustvo četiri hidrofobna domene.

Proteini posreduju u signalnim događajima transdukcije, gdje imaju ulogu u regulaciji razvoja, aktivacije, rasta i pokretljivosti ćelija. Ovaj kodirani protein nalazi se u asimetričnoj jedinici membrane (AUM), gdje se može kompleksirati s ostalim transmembranskim proteinima superporodice 4.

Može imati ulogu u normalnoj fiziologiji mjehurskog epitela, moguće u reguliranju propusnosti membrane površinskih kišobranastih ćelija ili u stabilizaciji apikalne membrane preko AUM / citoskelet ne interakcije.^[7]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MASAAAAEAE	KGSPVVVGLL	VVGNIIILLS	GLSLFAETIW	VTADQYRVYP
LMGVSGKDDV	FAGAWIAIFC	GFSFFMVASF	GVGAALCRRR	SMVLTYLVLM
LIVYIFECAS	CITSYTHRDY	MVSNPSLITK	QMLTFYSADT	DQGQELTRLW
DRVMIEQECC	GTSGPMDWVN	FTSAFRAATP	EVVFPWPPLC	CRRTGNFIPL
NEEGCRLGHM	DYLFTKGCFE	HIGHAIDSYT	WGISWFGFAI	LMWTLPVMLI
AMYFYTML

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105668 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006313 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
^ Yuasa T, Yoshiki T, Isono T, Tanaka T, Hayashida H, Okada Y (Sep 1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int J Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304. S2CID 43597402.
^ ^a ^b "Entrez Gene: UPK1A uroplakin 1A".

Dopunska literatura

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. PMID 11739647.
Yu J, Lin JH, Wu XR, Sun TT (1994). "Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins". J. Cell Biol. 125 (1): 171–82. doi:10.1083/jcb.125.1.171. PMC 2120008. PMID 8138569.
Wu XR, Medina JJ, Sun TT (1996). "Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells". J. Biol. Chem. 270 (50): 29752–9. doi:10.1074/jbc.270.50.29752. PMID 8530366.
Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. doi:10.1016/S0002-9440(10)65206-6. PMC 1867018. PMID 10514386.
Kageyama S, Yoshiki T, Isono T, et al. (2003). "High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma". Jpn. J. Cancer Res. 93 (5): 523–31. doi:10.1111/j.1349-7006.2002.tb01287.x. PMC 5927031. PMID 12036448.
Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell. 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMC 138628. PMID 12475947.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Yuasa T, Yoshiki T, Isono T, et al. (2004). "Molecular cloning and expression of uroplakins in transitional cell carcinoma". Bladder Disease, Part A. Adv. Exp. Med. Biol. 539. str. 33–46. doi:10.1007/978-1-4419-8889-8_3. ISBN 978-1-4613-4707-1. PMID 15088894.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hall GD, Weeks RJ, Olsburgh J, et al. (2005). "Transcriptional control of the human urothelial-specific gene, uroplakin Ia". Biochim. Biophys. Acta. 1729 (2): 126–34. doi:10.1016/j.bbaexp.2005.04.004. PMID 15913809.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105668 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006313 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9846985-5] Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.

[pmid10404304-6] Yuasa T, Yoshiki T, Isono T, Tanaka T, Hayashida H, Okada Y (Sep 1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int J Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304. S2CID 43597402.

[entrez-7] "Entrez Gene: UPK1A uroplakin 1A".

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