UNQ1887

Signalna peptidna peptidaza 3, znana i kao UNQ1887, je ljudski gen.

UNQ1887
Identifikatori
Aliasi	SPPL3
Vanjski ID-jevi	OMIM: 608240 MGI: 1891433 HomoloGene: 15563 GeneCards: SPPL3
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12q24.31 Početak 120,762,510 bp Kraj 120,904,358 bp
Lokacija gena (miš) Hrom. Hromosom 5 (miš) Bend 5|5 F Početak 115,149,196 bp Kraj 115,236,849 bp
Ontologija gena Molekularna funkcija • protein homodimerization activity • aspartic-type endopeptidase activity • aspartic endopeptidase activity, intramembrane cleaving • GO:0070122 peptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • hydrolase activity Ćelijska komponenta • integral component of membrane • rough endoplasmic reticulum • Golđijev aparat • endoplasmic reticulum membrane • membrana • intracellular membrane-bounded organelle • integral component of cytoplasmic side of endoplasmic reticulum membrane • ćelijska membrana • Endoplazmatski retikulum • Golgi-associated vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • lysosomal membrane Biološki proces • positive regulation of protein dephosphorylation • membrane protein proteolysis • positive regulation of cytosolic calcium ion concentration • Proteoliza • membrane protein ectodomain proteolysis • positive regulation of protein binding • T cell receptor signaling pathway • positive regulation of calcineurin-NFAT signaling cascade • signal peptide processing Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	121665	74585
Ensembl	ENSG00000157837	ENSMUSG00000029550
UniProt	Q8TCT6	Q9CUS9
RefSeq (mRNK)	NM_139015	NM_029012
RefSeq (bjelančevina)	NP_620584	NP_083288
Lokacija (UCSC)	Chr 12: 120.76 – 120.9 Mb	Chr 5: 115.15 – 115.24 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je proteina kojeg kodira je 385 aminokiselina, a molekulska težina 42.563 Da..

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin

R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAEQTYSWAY		SLVDSSQVST		FLISILLIVY		GSFRSLNMDF		ENQDKEKDSN
SSSGSFNGEQ		EPIIGFQPMD		STRARFLPMG		ACVSLLVMFF		FFDSVQVVFT
ICTAVLATIA		FAFLLLPMCQ		YLTRPCSPQN		KISFGCCGRF		TAAELLSFSL
SVMLVLIWVL		TGHWLLMDAL		AMGLCVAMIA		FVRLPSLKVS		CLLLSGLLIY
DVFWVFFSAY		IFNSNVMVKV		ATQPADNPLD		VLSRKLHLGP		NVGRDVPRLS
LPGKLVFPSS		TGSHFSMLGI		GDIVMPGLLL		CFVLRYDNYK		KQASGDSCGA
PGPANISGRM		QKVSYFHCTL		IGYFVGLLTA		TVASRIHRAA		QPALLYLVPF
TLLPLLTMAY		LKGDLRRMWS		EPFHSKSSSS		RFLEV

Dopunska literatura

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• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Weihofen A, Binns K, Lemberg MK, et al. (2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science. 296 (5576): 2215–8. doi:10.1126/science.1070925. PMID 12077416. S2CID 45633906.
• Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI (2003). "Novel class of polytopic proteins with domains associated with putative protease activity". Biochemistry Mosc. 67 (7): 826–35. doi:10.1023/A:1016365227942. PMID 12139484. S2CID 11785597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Friedmann E, Lemberg MK, Weihofen A, et al. (2005). "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins". J. Biol. Chem. 279 (49): 50790–8. doi:10.1074/jbc.M407898200. PMID 15385547.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Krawitz P, Haffner C, Fluhrer R, et al. (2006). "Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3". J. Biol. Chem. 280 (47): 39515–23. doi:10.1074/jbc.M501645200. PMID 15998642.
• Nyborg AC, Ladd TB, Jansen K, et al. (2006). "Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase". FASEB J. 20 (10): 1671–9. doi:10.1096/fj.06-5762com. PMID 16873890. S2CID 8233317.