MPHOSPH10

MPHOSPH10
Identifikatori
Aliasi	MPHOSPH10
Vanjski ID-jevi	OMIM: 605503 MGI: 1915223 HomoloGene: 134741 GeneCards: MPHOSPH10
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	71,150,101 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	64,042,016 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• sno(s)RNA-containing ribonucleoprotein complex; • small-subunit processome; • Mpp10 complex; • Jedarce; • jedro; • hromosom; • nukleoplazma;
Biološki proces	• RNA splicing, via transesterification reactions; • negative regulation of phosphatase activity; • GO:0033168, GO:0036404, GO:1902360 RNA processing; • ribosome biogenesis; • Prerada RNK; • rRNA processing; • maturation of SSU-rRNA;
	Izvori:Amigo / QuickGO
Ortolozi
	10199
	67973
	ENSG00000124383
	ENSMUSG00000030521
	O00566
	Q810V0
	NM_005791
	NM_026483
	NP_005782
	NP_080759
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

U3 mali jedarčani ribonukleoproteinski protein MPP10 jest protein koji je kod ljudi kodiran genom MPHOSPH10 sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 681 aminokiselina, a molkekulska iežina 78.864 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAPQVWRRRT	LERCLTEVGK	ATGRPECFLT	IQEGLASKFT	SLTKVLYDFN
KILENGRIHG	SPLQKLVIEN	FDDEQIWQQL	ELQNEPILQY	FQNAVSETIN
DEDISLLPES	EEQEREEDGS	EIEADDKEDL	EDLEEEEVSD	MGNDDPEMGE
RAENSSKSDL	RKSPVFSDED	SDLDFDISKL	EQQSKVQNKG	QGKPREKSIV
DDKFFKLSEM	EAYLENIEKE	EERKDDNDEE	EEDIDFFEDI	DSDEDEGGLF
GSKKLKSGKS	SRNLKYKDFF	DPVESDEDIT	NVHDDELDSN	KEDDEIAEEE
AEELSISETD	EDDDLQENED	NKQHKESLKR	VTFALPDDAE	TEDTGVLNVK
KNSDEVKSSF	EKRQEKMNEK	IASLEKELLE	KKPWQLQGEV	TAQKRPENSL
LEETLHFDHA	VRMAPVITEE	TTLQLEDIIK	QRIRDQAWDD	VVRKEKPKED
AYEYKKRLTL	DHEKSKLSLA	EIYEQEYIKL	NQQKTAEEEN	PEHVEIQKMM
DSLFLKLDAL	SNFHFIPKPP	VPEIKVVSNL	PAITMEEVAP	VSVSDAALLA
PEEIKEKNKA	GDIKTAAEKT	ATDKKRERRK	KKYQKRMKIK	EKEKRRKLLE
KSSVDQAGKY	SKTVASEKLK	QLTKTGKASF	IKDEGKDKAL	KSSQAFFSKL
QDQVKMQIND	AKKTEKKKKK	RQDISVHKLK	L

Funkcija

Ovaj gen kodira protein koji se fosforilira tokom mitoze. Protein se nalazi na nukleolusu tokom interfaze i na hromosomima tokom M-faze. Smatra se da je protein dio U3 malog jedarcetovog proteinskog kompleksa, koji je uključen u preradu rRNK.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124383 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030521 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
^ Westendorf JM, Konstantinov KN, Wormsley S, Shu MD, Matsumoto-Taniura N, Pirollet F, Klier FG, Gerace L, Baserga SJ (Mar 1998). "M Phase Phosphoprotein 10 Is a Human U3 Small Nucleolar Ribonucleoprotein Component". Mol Biol Cell. 9 (2): 437–49. doi:10.1091/mbc.9.2.437. PMC 25272. PMID 9450966.
^ ^a ^b "Entrez Gene: MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)".
^ "UniProt, O00566" (jezik: engleski). Pristupljeno 13. 11. 2021.

Dopunska literatura

Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60–80S ribonucleoprotein complexes". Nucleic Acids Res. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC 152815. PMID 12655004.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

MPHOSPH10 lokacija ljudskog genoma UCSC Genome Browser.

MPHOSPH10 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124383 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030521 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8885239-5] Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.

[pmid9450966-6] Westendorf JM, Konstantinov KN, Wormsley S, Shu MD, Matsumoto-Taniura N, Pirollet F, Klier FG, Gerace L, Baserga SJ (Mar 1998). "M Phase Phosphoprotein 10 Is a Human U3 Small Nucleolar Ribonucleoprotein Component". Mol Biol Cell. 9 (2): 437–49. doi:10.1091/mbc.9.2.437. PMC 25272. PMID 9450966.

[entrez-7] "Entrez Gene: MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)".

[UniProt-8] "UniProt, O00566" (jezik: engleski). Pristupljeno 13. 11. 2021.

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