TMED4

TMED4
Identifikatori
Aliasi	TMED4
Vanjski ID-jevi	OMIM: 612038 MGI: 1915070 HomoloGene: 5308 GeneCards: TMED4
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	44,582,287 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	6,224,870 bp
Ontologija gena
Molekularna funkcija	• signal transducer activity;
Ćelijska komponenta	• integral component of membrane; • Egzosom; • endoplasmic reticulum membrane; • Endoplazmatski retikulum; • membrana;
Biološki proces	• protein transport; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • GO:0072468 Transdukcija signala; • GO:0015915 transport;
	Izvori:Amigo / QuickGO
Ortolozi
	222068
	103694
	ENSG00000158604
	ENSMUSG00000004394
	Q7Z7H5
	Q8R1V4
NM_182547; NM_001303058; NM_001303059; NM_001303060; NM_001303061;
	NM_001303062
	NM_134020
NP_001289987; NP_001289988; NP_001289989; NP_001289990; NP_001289991;
	NP_872353
	NP_598781
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski protein 4 emp24 sa domenom je protein koji je kod ljudi kodiran genom TMED4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 227 aminokiselina, a molekulska težina 25.943 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGVGAGPLR	AMGRQALLLL	ALCATGAQGL	YFHIGETEKR	CFIEEIPDET
MVIGNYRTQM	WDKQKEVFLP	STPGLGMHVE	VKDPDGKVVL	SRQYGSEGRF
TFTSHTPGDH	QICLHSNSTR	MALFAGGKLR	VHLDIQVGEH	ANNYPEIAAK
DKLTELQLRA	RQLLDQVEQI	QKEQDYQRYR	EERFRLTSES	TNQRVLWWSI
AQTVILILTG	IWQMRHLKSF	FEAKKLV

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158604 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004394 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501.
^ "Entrez Gene: TMED4 transmembrane emp24 protein transport domain containing 4".
^ "UniProt, Q7Z7H5" (jezik: engleski). Pristupljeno 30. 9. 2021.

Dopunska literatura

Matoba R; Okubo K; Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S; Weil B; Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW; Cheung J; MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S; Arlt D; Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Otsuki T; Ota T; Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A; Rosenfelder H; Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158604 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004394 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12761501-5] Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501.

[entrez-6] "Entrez Gene: TMED4 transmembrane emp24 protein transport domain containing 4".

[UniProt-7] "UniProt, Q7Z7H5" (jezik: engleski). Pristupljeno 30. 9. 2021.

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