TMED1

TMED1
Identifikatori
Aliasi	TMED1
Vanjski ID-jevi	OMIM: 605395 MGI: 106201 HomoloGene: 21360 GeneCards: TMED1
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	10,836,318 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	21,421,548 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• signaling receptor binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • Golđijev aparat; • endoplasmic reticulum-Golgi intermediate compartment membrane; • endoplasmic reticulum-Golgi intermediate compartment; • ćelijska membrana; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum; • COPII-coated ER to Golgi transport vesicle;
Biološki proces	• protein transport; • GO:0072468 Transdukcija signala; • cell-cell signaling; • intracellular protein transport; • endoplasmic reticulum to Golgi vesicle-mediated transport; • Golgi organization;
	Izvori:Amigo / QuickGO
Ortolozi
	11018
	17083
	ENSG00000099203
	ENSMUSG00000032180
	Q13445
	Q3V009
	NM_006858
	NM_010744; NM_001324510
	NP_006849
	NP_001311439; NP_034874
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski emp24 domen-sadržavajući protein 1 je protein koji je kod ljudi kodiran genom TMED1.^[5]^[6]^[7]

Protein kodiran ovim genom identificiran je njegovom interakcijom s receptorima poput interleukina 1 (IL1RL1). Ovaj protein nema nikakve sličnosti s drugim ligandima interleukina 1. Funkcionalni značaj njegove interakcije s IL1RL1 nije poznat.^[7]

Aminokiselinska sekvenca uredi

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MMAAGAALAL	ALWLLMPPVE	VGGAGPPPIQ	DGEFTFLLPA	GRKQCFYQSA
PANASLETEY	QVIGGAGLDV	DFTLESPQGV	LLVSESRKAD	GVHTVEPTEA
GDYKLCFDNS	FSTISEKLVF	FELIFDSLQD	DEEVEGWAEA	VEPEEMLDVK
MEDIKESIET	MRTRLERSIQ	MLTLLRAFEA	RDRNLQEGNL	ERVNFWSAVN
VAVLLLVAVL	QVCTLKRFFQ	DKRPVPT

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032180 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.
^ Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.
^ ^a ^b "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

Dopunska literatura uredi

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032180 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11466339-5] Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.

[pmid8621446-6] Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.

[entrez-7] "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

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