TICAM2
Adapterska molekula 2 sa domenom TIR je protein koji je kod ljudi kodiran genom TICAM2.[5]
TIRP je toll/interleukinski-1 receptor (IL1R; MIM 147810) (TIR) adapterski prptein sa domenom, uključenim u signalizaciju Toll-receptora (vidi: TLR4; MIM 603030; prema OMIM)[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 235 aminokiselina, a molekulska težina Da. 26 916[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGIGKSKINS | CPLSLSWGKR | HSVDTSPGYH | ESDSKKSEDL | SLCNVAEHSN | ||||
| TTEGPTGKQE | GAQSVEEMFE | EEAEEEVFLK | FVILHAEDDT | DEALRVQNLL | ||||
| QDDFGIKPGI | IFAEMPCGRQ | HLQNLDDAVN | GSAWTILLLT | ENFLRDTWCN | ||||
| FQFYTSLMNS | VNRQHKYNSV | IPMRPLNNPL | PRERTPFALQ | TINALEEESR | ||||
| GFPTQVERIF | QESVYKTQQT | IWKETRNMVQ | RQFIA |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000243414 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056130 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2".
- ^ "UniProt, Q86XR7" (jezik: англ.). Pristupljeno 15. 10. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
uredi- Sullivan C, Postlethwait JH, Lage CR, et al. (2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". J. Immunol. 178 (7): 4517–27. doi:10.4049/jimmunol.178.7.4517. PMID 17372010.
- Rowe DC, McGettrick AF, Latz E, et al. (2006). "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. doi:10.1073/pnas.0510041103. PMC 1458872. PMID 16603631.
- Yamamoto M, Sato S, Hemmi H, et al. (2003). "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway". Nat. Immunol. 4 (11): 1144–50. doi:10.1038/ni986. PMID 14556004. S2CID 13016860.
- Oshiumi H, Sasai M, Shida K, et al. (2004). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta". J. Biol. Chem. 278 (50): 49751–62. doi:10.1074/jbc.M305820200. PMID 14519765.
- Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
- Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.