THAP2

THAP2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2D8R
Identifikatori
Aliasi	THAP2
Vanjski ID-jevi	OMIM: 612531 MGI: 1914066 HomoloGene: 12039 GeneCards: THAP2
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	71,680,644 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	115,220,348 bp
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • vezivanje sa DNK; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• Jedarce;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	83591
	66816
	ENSG00000173451
	ENSMUSG00000020137
	Q9H0W7
	Q9D305
	NM_031435
	NM_025780
	NP_113623
	NP_080056
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

THAP protein 2 sa domenom je protein koji je kod ljudi kodiran genom THAP2.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 228 aminokiselina, a molekulska težina 26 260 Da.^[7].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPTNCAAAGC	ATTYNKHINI	SFHRFPLDPK	RRKEWVRLVR	RKNFVPGKHT
FLCSKHFEAS	CFDLTGQTRR	LKMDAVPTIF	DFCTHIKSMK	LKSRNLLKKN
NSCSPAGPSN	LKSNISSQQV	LLEHSYAFRN	PMEAKKRIIK	LEKEIASLRR
KMKTCLQKER	RATRRWIKAT	CLVKNLEANS	VLPKGTSEHM	LPTALSSLPL
EDFKILEQDQ	QDKTLLSLNL	KQTKSTFI

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173451 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020137 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
^ "Entrez Gene: THAP2 THAP domain containing, apoptosis associated protein 2".
^ "UniProt, Q9H0W7". Pristupljeno 14. 8. 2021.

Dopunska literatura

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173451 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020137 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12575992-5] Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.

[entrez-6] "Entrez Gene: THAP2 THAP domain containing, apoptosis associated protein 2".

[UniProt-7] "UniProt, Q9H0W7". Pristupljeno 14. 8. 2021.

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