TGOLN2

TGOLN2
Identifikatori
Aliasi	TGOLN2
Vanjski ID-jevi	OMIM: 603062 HomoloGene: 136490 GeneCards: TGOLN2
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	85,328,251 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • trans-Golđijeva mreža; • Golđijev aparat; • trans-Golgi network transport vesicle; • transport vesicle; • membrana; • nukleoplazma; • citosol; • ćelijska membrana; • clathrin-coated vesicle membrane; • endoplasmic reticulum lumen; • endozom;
Biološki proces	• Golgi to endosome transport; • membrane organization; • Posttranslacione modifikacije;
	Izvori:Amigo / QuickGO
Ortolozi
	10618
	n/a
	ENSG00000152291
	n/a
	O43493
	n/a
NM_006464; NM_001206840; NM_001206841; NM_001206844; NM_001368095;
	NM_001368096
	n/a
NP_001193769; NP_001193770; NP_001193773; NP_006455; NP_001355024;
	NP_001355025
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Integralni membranski protein 2 trans-Golgijeve mreže jest protein koji je kod ljudi kodiran genom TGOLN2 sa hromosoma 2.^[3]^[4]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 480 aminokiselina, a molekulska težina 51.113 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRFVVALVLL	NVAAAGAVPL	LATESVKQEE	AGVRPSAGNV	STHPSLSQRP
GGSTKSHPEP	QTPKDSPSKS	SAEAQTPEDT	PNKSGAEAKT	QKDSSNKSGA
EAKTQKGSTS	KSGSEAQTTK	DSTSKSHPEL	QTPKDSTGKS	GAEAQTPEDS
PNRSGAEAKT	QKDSPSKSGS	EAQTTKDVPN	KSGADGQTPK	DGSSKSGAED
QTPKDVPNKS	GAEKQTPKDG	SNKSGAEEQG	PIDGPSKSGA	EEQTSKDSPN
KVVPEQPSRK	DHSKPISNPS	DNKELPKADT	NQLADKGKLS	PHAFKTESGE
ETDLISPPQE	EVKSSEPTED	VEPKEAEDDD	TGPEEGSPPK	EEKEKMSGSA
SSENREGTLS	DSTGSEKDDL	YPNGSGNGSA	ESSHFFAYLV	TAAILVAVLY
IAHHNKRKII	AFVLEGKRSK	VTRRPKASDY	QRLDQKYVLI	LNVFPAPPKR
SFLPQVLTEW	YIPLEKDERH	QWIVLLSFQL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152291 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kain R, Angata K, Kerjaschki D, Fukuda M (Feb 1998). "Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs". J Biol Chem. 273 (2): 981–8. doi:10.1074/jbc.273.2.981. PMID 9422759.
^ "Entrez Gene: TGOLN2 trans-golgi network protein 2".
^ "UniProt, O43493" (jezik: engleski). Pristupljeno 14. 11. 2021.

Dopunska literatura

Ohno H, Stewart J, Fournier MC, et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science. 269 (5232): 1872–5. doi:10.1126/science.7569928. PMID 7569928.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Ponnambalam S, Girotti M, Yaspo ML, et al. (1997). "Primate homologues of rat TGN38: primary structure, expression and functional implications". J. Cell Sci. 109 (3): 675–85. doi:10.1242/jcs.109.3.675. PMID 8907712.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". Biochem. J. 335 (Pt 3): 567–72. doi:10.1042/bj3350567. PMC 1219817. PMID 9794796.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
Wang J, Howell KE (2001). "The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking". Traffic. 1 (9): 713–23. doi:10.1034/j.1600-0854.2000.010904.x. PMID 11208159. S2CID 22784729.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yeaman C, Ayala MI, Wright JR, et al. (2004). "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network". Nat. Cell Biol. 6 (2): 106–12. doi:10.1038/ncb1090. PMC 3372901. PMID 14743217.
Höning S, Ricotta D, Krauss M, et al. (2005). "Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2" (PDF). Mol. Cell. 18 (5): 519–31. doi:10.1016/j.molcel.2005.04.019. hdl:11379/18706. PMID 15916959.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152291 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9422759-3] Kain R, Angata K, Kerjaschki D, Fukuda M (Feb 1998). "Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs". J Biol Chem. 273 (2): 981–8. doi:10.1074/jbc.273.2.981. PMID 9422759.

[entrez-4] "Entrez Gene: TGOLN2 trans-golgi network protein 2".

[UniProt-5] "UniProt, O43493" (jezik: engleski). Pristupljeno 14. 11. 2021.

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