TBC1D15
Član 15 domenske porodice TBC1 je protein koji je kod ljudi kodiran genom TBC1D15.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 691 aminokiselinu, a molekulska težina 79.491 Da.[7]
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAAAGVVSGK | IIYEQEGVYI | HSSCGKTNDQ | DGLISGILRV | LEKDAEVIVD | ||||
| WRPLDDALDS | SSILYARKDS | SSVVEWTQAP | KERGHRGSEH | LNSYEAEWDM | ||||
| VNTVSFKRKP | HTNGDAPSHR | NGKSKWSFLF | SLTDLKSIKQ | NKEGMGWSYL | ||||
| VFCLKDDVVL | PALHFHQGDS | KLLIESLEKY | VVLCESPQDK | RTLLVNCQNK | ||||
| SLSQSFENLL | DEPAYGLIQA | GLLDRRKLLW | AIHHWKKIKK | DPYTATMIGF | ||||
| SKVTNYIFDS | LRGSDPSTHQ | RPPSEMADFL | SDAIPGLKIN | QQEEPGFEVI | ||||
| TRIDLGERPV | VQRREPVSLE | EWTKNIDSEG | RILNVDNMKQ | MIFRGGLSHA | ||||
| LRKQAWKFLL | GYFPWDSTKE | ERTQLQKQKT | DEYFRMKLQW | KSISQEQEKR | ||||
| NSRLRDYRSL | IEKDVNRTDR | TNKFYEGQDN | PGLILLHDIL | MTYCMYDFDL | ||||
| GYVQGMSDLL | SPLLYVMENE | VDAFWCFASY | MDQMHQNFEE | QMQGMKTQLI | ||||
| QLSTLLRLLD | SGFCSYLESQ | DSGYLYFCFR | WLLIRFKREF | SFLDILRLWE | ||||
| VMWTELPCTN | FHLLLCCAIL | ESEKQQIMEK | HYGFNEILKH | INELSMKIDV | ||||
| EDILCKAEAI | SLQMVKCKEL | PQAVCEILGL | QGSEVTTPDS | DVGEDENVVM | ||||
| TPCPTSAFQS | NALPTLSASG | ARNDSPTQIP | VSSDVCRLTP | A |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000121749 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020130 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- ^ "Entrez Gene: TBC1D15 TBC1 domain family, member 15".
- ^ "UniProt, Q8TC07". Pristupljeno 14. 8. 2021.
Dopunska literatura
uredi- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Zhang XM, Walsh B, Mitchell CA, Rowe T (2005). "TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7". Biochem. Biophys. Res. Commun. 335 (1): 154–61. doi:10.1016/j.bbrc.2005.07.070. PMID 16055087.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.