Wikipedia

TAF1D

(TBP)-pridruženi faktor proteinskog vezanja RNK polimeraze I TATA-kutije od 41kDa je protein koji je kod ljudi kodiran genom TAF1D.[5]

TAF1D
Identifikatori
AliasiTAF1D
Vanjski ID-jeviOMIM: 612823 MGI: 1922566 HomoloGene: 11472 GeneCards: TAF1D
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za TAF1D
Genomska lokacija za TAF1D
Bend11q21Početak93,729,948 bp[1]
Kraj93,784,391 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za TAF1D
Genomska lokacija za TAF1D
Bend9|9 A2Početak15,306,214 bp[2]
Kraj15,316,991 bp[2]
Ontologija gena
Molekularna funkcija• vezivanje sa DNK
• GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta• RNA polymerase transcription factor SL1 complex
• jedro
• nukleoplazma
• centar organizacije mikrotubula
Biološki proces• transcription initiation from RNA polymerase I promoter
• termination of RNA polymerase I transcription
• epigenetic maintenance of chromatin in transcription-competent conformation
• GO:0009373 regulation of transcription, DNA-templated
• transcription, DNA-templated
• GO:0001183 transcription elongation from RNA polymerase I promoter
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

79101

75316

Ensembl

ENSG00000166012

ENSMUSG00000031939

UniProt

Q9H5J8

Q9D4V4

RefSeq (mRNK)

NM_024116

NM_026541
NM_027261
NM_029248

RefSeq (bjelančevina)

NP_077021

NP_081537
NP_083524

Lokacija (UCSC)Chr 11: 93.73 – 93.78 MbChr 9: 15.31 – 15.32 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 278 aminokiselina, а molekulska težina 32.058 Da.[6]

1020304050
MDKSGIDSLDHVTSDAVELANRSDNSSDSSLFKTQCIPYSPKGEKRNPIR
KFVRTPESVHASDSSSDSSFEPIPLTIKAIFERFKNRKKRYKKKKKRRYQ
PTGRPRGRPEGRRNPIYSLIDKKKQFRSRGSGFPFLESENEKNAPWRKIL
TFEQAVARGFFNYIEKLKYEHHLKESLKQMNVGEDLENEDFDSRRYKFLD
DDGSISPIEESTAEDEDATHLEDNECDIKLAGDSFIVSSEFPVRLSVYLE
EEDITEEAALSKKRATKAKNTGQRGLKM

Funkcija

uredi

TAF1D je član SL1 kompleksa, koji uključuje TBP i TAF1A, TAF1B i TAF1C, a ima ulogu u transkripciji RNK-polimeraza I.[7][8]

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166012 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031939 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa".
  6. ^ "UniProt, Q9H5J8". Pristupljeno 27. 8. 2021.
  7. ^ Wang L, Bhattacharyya N, Chelsea DM, Escobar PF, Banerjee S (novembar 2004). "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype". Cancer Research. 64 (21): 7673–7. doi:10.1158/0008-5472.CAN-04-2801. PMID 15520167.
  8. ^ Gorski JJ, Pathak S, Panov K, Kasciukovic T, Panova T, Russell J, Zomerdijk JC (mart 2007). "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription". The EMBO Journal. 26 (6): 1560–8. doi:10.1038/sj.emboj.7601601. PMC 1829371. PMID 17318177.
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