STYXL1

STYXL1
Identifikatori
Aliasi	STYXL1
Vanjski ID-jevi	OMIM: 616695 MGI: 1923821 HomoloGene: 9378 GeneCards: STYXL1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	76,048,004 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	135,807,239 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hydrolase activity; • protein tyrosine/serine/threonine phosphatase activity; • phosphoprotein phosphatase activity; • pseudophosphatase activity; • protein phosphatase inhibitor activity; • GO:0001948, GO:0016582 vezivanje za proteine; • protein phosphatase binding;
Ćelijska komponenta	• mitohondrija; • mitochondrial matrix;
Biološki proces	• GO:0007243 intracellular signal transduction; • GO:0016576 protein dephosphorylation; • GO:0098501, GO:0098502, GO:0006286 Defosforilacija; • positive regulation of neuron projection development; • negative regulation of phosphoprotein phosphatase activity; • regulation of intrinsic apoptotic signaling pathway; • positive regulation of intrinsic apoptotic signaling pathway; • negative regulation of stress granule assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	51657
	76571
	ENSG00000127952
	ENSMUSG00000019178
	Q9Y6J8
	n/a
NM_016086; NM_001317785; NM_001317786; NM_001317787; NM_001317788;
	NM_001317789
	NM_001289554; NM_001289555; NM_001289556; NM_001289557; NM_029659
NP_001304714; NP_001304715; NP_001304716; NP_001304717; NP_001304718;
	NP_057170
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Serin/treonin/tirozin-interaktivnoliki protein 1 jest protein koji je kod ljudi kodiran genom STYXL1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 313 aminokiselina, а molekulska težina 35.818 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPGLLLCEPT	ELYNILNQAT	KLSRLTDPNY	LCLLDVRSKW	EYDESHVITA
LRVKKKNNEY	LLPESVDLEC	VKYCVVYDNN	SSTLEILLKD	DDDDSDSDGD
GKDLVPQAAI	EYGRILTRLT	HHPVYILKGG	YERFSGTYHF	LRTQKIIWMP
QELDAFQPYP	IEIVPGKVFV	GNFSQACDPK	IQKDLKIKAH	VNVSMDTGPF
FAGDADKLLH	IRIEDSPEAQ	ILPFLRHMCH	FIEIHHHLGS	VILIFSTQGI
SRSCAAIIAY	LMHSNEQTLQ	RSWAYVKKCK	NNMCPNRGLV	SQLLEWEKTI
LGDSITNIMD	PLY

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127952 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019178 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wishart MJ, Dixon JE (Oct 1998). "Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains". Trends Biochem Sci. 23 (8): 301–6. doi:10.1016/S0968-0004(98)01241-9. PMID 9757831.
^ "Entrez Gene: STYXL1 serine/threonine/tyrosine interacting-like 1".
^ "UniProt, Q9Y6J8" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Siligan C, Ban J, Bachmaier R, et al. (2005). "EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin". Oncogene. 24 (15): 2512–24. doi:10.1038/sj.onc.1208455. PMID 15735734.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127952 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019178 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9757831-5] Wishart MJ, Dixon JE (Oct 1998). "Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains". Trends Biochem Sci. 23 (8): 301–6. doi:10.1016/S0968-0004(98)01241-9. PMID 9757831.

[entrez-6] "Entrez Gene: STYXL1 serine/threonine/tyrosine interacting-like 1".

[UniProt-7] "UniProt, Q9Y6J8" (jezik: engleski). Pristupljeno 29. 9. 2021.

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