STRBP

Spermatidni perijedarni RNK-vezujući protein je protein koji je kod ljudi kodiran genom STRBP.

STRBP
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2DMY
Identifikatori
Aliasi	STRBP
Vanjski ID-jevi	OMIM: 611138 MGI: 104626 HomoloGene: 7548 GeneCards: STRBP
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek) Bend 9q33.3 Početak 123,109,500 bp Kraj 123,268,586 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 B Početak 37,373,240 bp Kraj 37,593,871 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • double-stranded RNA binding • GO:0001948, GO:0016582 vezivanje za proteine • single-stranded RNA binding • vezivanje sa RNK • microtubule binding • vezivanje tubulina Ćelijska komponenta • citoplazma • microtubule cytoskeleton • jedro • manchette Biološki proces • multicellular organism development • mechanosensory behavior • Ćelijska diferencijacija • Spermatogeneza • spermatid development Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	55342	20744
Ensembl	ENSG00000165209	ENSMUSG00000026915
UniProt	Q96SI9	Q91WM1
RefSeq (mRNK)	NM_001171137 NM_018387 NM_001376106 NM_001376107 NM_001376109	NM_009261 NM_176932 NM_001355259 NM_001379314 NM_001379315 NM_001379316
RefSeq (bjelančevina)	NP_001164608 NP_060857 NP_001363035 NP_001363036 NP_001363038	NP_033287 NP_001342188 NP_001366243 NP_001366244 NP_001366245
Lokacija (UCSC)	Chr 9: 123.11 – 123.27 Mb	Chr 2: 37.37 – 37.59 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 672 aminokiseline, а molekulska težina 73.653 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MRSIRSFAND		DRHVMVKHST		IYPSPEELEA		VQNMVSTVEC		ALKHVSDWLD
ETNKGTKTEG		ETEVKKDEAG		ENYSKDQGGR		TLCGVMRIGL		VAKGLLIKDD
MDLELVLMCK		DKPTETLLNT		VKDNLPIQIQ		KLTEEKYQVE		QCVNEASIII
RNTKEPTLTL		KVILTSPLIR		DELEKKDGEN		VSMKDPPDLL		DRQKCLNALA
SLRHAKWFQA		RANGLKSCVI		VLRILRDLCN		RVPTWAPLKG		WPLELICEKS
IGTCNRPLGA		GEALRRVMEC		LASGILLPGG		PGLHDPCERD		PTDALSYMTI
QQKEDITHSA		QHALRLSAFG		QIYKVLEMDP		LPSSKPFQKY		SWSVTDKEGA
GSSALKRPFE		DGLGDDKDPN		KKMKRNLRKI		LDSKAIDLMN		ALMRLNQIRP
GLQYKLLSQS		GPVHAPVFTM		SVDVDGTTYE		ASGPSKKTAK		LHVAVKVLQA
MGYPTGFDAD		IECMSSDEKS		DNESKNETVS		SNSSNNTGNS		TTETSSTLEV
RTQGPILTAS		GKNPVMELNE		KRRGLKYELI		SETGGSHDKR		FVMEVEVDGQ
KFRGAGPNKK		VAKASAALAA		LEKLFSGPNA		ANNKKKKIIP		QAKGVVNTAV
SAAVQAVRGR		GRGTLTRGAF		VGATAAPGYI		APGYGTPYGY		STAAPAYGLP
KRMVLLPVMK		FPTYPVPHYS		FF

Dopunska literatura

• Schumacher JM, Lee K, Edelhoff S, Braun RE (maj 1995). "Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules". The Journal of Cell Biology. 129 (4): 1023–32. doi:10.1083/jcb.129.4.1023. PMC 2120489. PMID 7744952.
• Schumacher JM, Artzt K, Braun RE (juli 1998). "Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice". Biology of Reproduction. 59 (1): 69–76. doi:10.1095/biolreprod59.1.69. PMID 9674995.
• Coolidge CJ, Patton JG (mart 2000). "A new double-stranded RNA-binding protein that interacts with PKR". Nucleic Acids Research. 28 (6): 1407–17. doi:10.1093/nar/28.6.1407. PMC 111047. PMID 10684936.
• Hartley JL, Temple GF, Brasch MA (novembar 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (septembar 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Pires-daSilva A, Nayernia K, Engel W, Torres M, Stoykova A, Chowdhury K, Gruss P (maj 2001). "Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities" (PDF). Developmental Biology. 233 (2): 319–28. doi:10.1006/dbio.2001.0169. hdl:11858/00-001M-0000-0012-F717-7. PMID 11336498.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (oktobar 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (oktobar 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (januar 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.