STOML2

STOML2
Identifikatori
Aliasi	STOML2
Vanjski ID-jevi	OMIM: 608292 MGI: 1913842 HomoloGene: 8389 GeneCards: STOML2
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	35,103,195 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	43,031,710 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cardiolipin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GTPase binding; • signaling receptor binding; • lipid binding;
Ćelijska komponenta	• citoplazma; • membrana; • mitochondrial intermembrane space; • ćelijska membrana; • T cell receptor complex; • mitohondrija; • immunological synapse; • actin cytoskeleton; • Lipidni splav; • COP9 signalosome; • extrinsic component of plasma membrane; • citoskelet; • mitochondrial inner membrane;
Biološki proces	• CD4-positive, alpha-beta T cell activation; • mitochondrial ATP synthesis coupled proton transport; • mitochondrion organization; • cellular calcium ion homeostasis; • positive regulation of mitochondrial DNA replication; • mitochondrial protein processing; • lipid localization; • protein complex oligomerization; • stress-induced mitochondrial fusion; • positive regulation of cardiolipin metabolic process; • positive regulation of mitochondrial membrane potential; • T cell receptor signaling pathway; • interleukin-2 production; • mitochondrial calcium ion transmembrane transport;
	Izvori:Amigo / QuickGO
Ortolozi
	30968
	66592
	ENSG00000165283
	ENSMUSG00000028455
	Q9UJZ1
	Q99JB2
	NM_013442; NM_001287031; NM_001287032; NM_001287033
	NM_023231
	NP_001273960; NP_001273961; NP_001273962; NP_038470
	NP_075720
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Stomatinoliki protein 2 je protein koji je kod ljudi kodiran genom STOML2.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 356 aminokiselina, а molekulska težina 38.534 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLARAARGTG	ALLLRGSLLA	SGRAPRRASS	GLPRNTVVLF	VPQQEAWVVE
RMGRFHRILE	PGLNILIPVL	DRIRYVQSLK	EIVINVPEQS	AVTLDNVTLQ
IDGVLYLRIM	DPYKASYGVE	DPEYAVTQLA	QTTMRSELGK	LSLDKVFRER
ESLNASIVDA	INQAADCWGI	RCLRYEIKDI	HVPPRVKESM	QMQVEAERRK
RATVLESEGT	RESAINVAEG	KKQAQILASE	AEKAEQINQA	AGEASAVLAK
AKAKAEAIRI	LAAALTQHNG	DAAASLTVAE	QYVSAFSKLA	KDSNTILLPS
NPGDVTSMVA	QAMGVYGALT	KAPVPGTPDS	LSSGSSRDVQ	GTDASLDEEL
DRVKMS

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165283 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028455 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Morrow JS (Apr 2000). "Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues". J Biol Chem. 275 (11): 8062–71. doi:10.1074/jbc.275.11.8062. PMID 10713127.
^ Hajek P, Chomyn A, Attardi G (Feb 2007). "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2" (PDF). J Biol Chem. 282 (8): 5670–81. doi:10.1074/jbc.M608168200. PMID 17121834. S2CID 2167533.
^ "Entrez Gene: STOML2 stomatin (EPB72)-like 2".
^ "UniProt, Q9UJZ1". Pristupljeno 12. 9. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Owczarek CM, Treutlein HR, Portbury KJ, et al. (2001). "A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1". Cytogenet. Cell Genet. 92 (3–4): 196–203. doi:10.1159/000056902. PMID 11435687. S2CID 19349691.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
Zhang L, Ding F, Cao W, et al. (2006). "Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma". Clin. Cancer Res. 12 (5): 1639–46. doi:10.1158/1078-0432.CCR-05-1858. PMID 16533792.
John JP, Anrather D, Pollak A, Lubec G (2006). "Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure". Proteins. 64 (2): 543–51. doi:10.1002/prot.20987. PMID 16671055. S2CID 24782924.
Cui Z, Zhang L, Hua Z, et al. (2007). "Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma". Oncol. Rep. 17 (4): 829–33. doi:10.3892/or.17.4.829. PMID 17342323.
Cao W, Zhang B, Liu Y, et al. (2007). "High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival". Am. J. Clin. Pathol. 128 (3): 430–6. doi:10.1309/C6X54HRB580EP2NQ. PMID 17709317.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165283 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028455 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10713127-5] Wang Y, Morrow JS (Apr 2000). "Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues". J Biol Chem. 275 (11): 8062–71. doi:10.1074/jbc.275.11.8062. PMID 10713127.

[pmid17121834-6] Hajek P, Chomyn A, Attardi G (Feb 2007). "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2" (PDF). J Biol Chem. 282 (8): 5670–81. doi:10.1074/jbc.M608168200. PMID 17121834. S2CID 2167533.

[entrez-7] "Entrez Gene: STOML2 stomatin (EPB72)-like 2".

[UniProt-8] "UniProt, Q9UJZ1". Pristupljeno 12. 9. 2021.

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