STC2
Staniokalcin-2 jest protein koji je kod ljudi kodiran genom STC2 sa hromosoma 5.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 302 aminokiseline, а molekulska težina 33.249 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MCAERLGQFM | TLALVLATFD | PARGTDATNP | PEGPQDRSSQ | QKGRLSLQNT | ||||
| AEIQHCLVNA | GDVGCGVFEC | FENNSCEIRG | LHGICMTFLH | NAGKFDAQGK | ||||
| SFIKDALKCK | AHALRHRFGC | ISRKCPAIRE | MVSQLQRECY | LKHDLCAAAQ | ||||
| ENTRVIVEMI | HFKDLLLHEP | YVDLVNLLLT | CGEEVKEAIT | HSVQVQCEQN | ||||
| WGSLCSILSF | CTSAIQKPPT | APPERQPQVD | RTKLSRAHHG | EAGHHLPEPS | ||||
| SRETGRGAKG | ERGSKSHPNA | HARGRVGGLG | AQGPSGSSEW | EDEQSEYSDI | ||||
| RR |
Funkcija
urediOvaj gen kodira izlučeni, homodimerni glikoprotein koji je eksprimiran u velikom broju tkiva i može imati autokrine ili parakrine funkcije. Kodirani protein ima 10 od svojih 15 konzerviranih cisteinskih ostataka među staniokalcinskim članovima porodice i fosforiliziranih pomoću kazein-kinaze 2 isključivo na svojim ostacima serina.
Njegov C-kraj sadrži skupinu histidinskih ostataka koji mogu stupiti u interakciju s metalnim ionima. Protein može imati ulogu u regulaciji transporta bubrežnog i crijevnog kalcija i fosfata, ćelijskog metabolizma ili homeostaze ćelijskog kalcija/fosfata. Konstitutivna prekomjerna ekspresija ljudskog staniokalcina 2 kod miševa rezultirala je pre- i postnatalnim ograničenjem rasta, smanjenim rastom kostiju i skeletnih mišića i organomegalijom. Ekspresiju ovog gena inducira estrogen i mijenja u nekim slučajevima raka dojke.[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000113739 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020303 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chang AC, Reddel RR (Nov 1998). "Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2". Mol Cell Endocrinol. 141 (1–2): 95–9. doi:10.1016/S0303-7207(98)00097-5. PMID 9723890. S2CID 28106090.
- ^ Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai M (Nov 1998). "Molecular cloning of a second human stanniocalcin homologue (STC2)". Biochem Biophys Res Commun. 250 (2): 252–8. doi:10.1006/bbrc.1998.9300. PMID 9753616.
- ^ a b "Entrez Gene: STC2 stanniocalcin 2".
- ^ "UniProt, O76061" (jezik: engleski). Pristupljeno 20. 10. 2021.
Dopunska literatura
uredi- DiMattia GE, Varghese R, Wagner GF (1999). "Molecular cloning and characterization of stanniocalcin-related protein". Mol. Cell. Endocrinol. 146 (1–2): 137–40. doi:10.1016/S0303-7207(98)00163-4. PMID 10022771. S2CID 27861622.
- Moore EE, Kuestner RE, Conklin DC, et al. (1999). "Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells". Horm. Metab. Res. 31 (7): 406–14. doi:10.1055/s-2007-978764. PMID 10450831.
- Jellinek DA, Chang AC, Larsen MR, et al. (2001). "Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells". Biochem. J. 350 Pt 2 (2): 453–61. doi:10.1042/0264-6021:3500453. PMC 1221272. PMID 10947959.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gagliardi AD, Kuo EY, Raulic S, et al. (2005). "Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs". Am. J. Physiol. Endocrinol. Metab. 288 (1): E92–105. doi:10.1152/ajpendo.00268.2004. PMID 15367391.
- Luo CW, Pisarska MD, Hsueh AJ (2005). "Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary". Endocrinology. 146 (1): 469–76. doi:10.1210/en.2004-1197. PMID 15486227.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Esseghir S, Kennedy A, Seedhar P, et al. (2007). "Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins". Clin. Cancer Res. 13 (11): 3164–73. doi:10.1158/1078-0432.CCR-07-0224. PMID 17545519.
- Ichikawa T, Horie-Inoue K, Ikeda K, et al. (2007). "Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells". J. Mol. Endocrinol. 39 (4): 239–47. doi:10.1677/JME-07-0048. PMID 17909264.