Protein 1 spermatogenog leucinskog zatvarača jest protein koji je kod ljudi kodiran genom SPZ1 sa hromosoma 5. is a protein that in humans is encoded by the [[gen.[5][6][7][8][9][10]

SPZ1
Identifikatori
AliasiSPZ1
Vanjski ID-jeviOMIM: 618068 MGI: 1930801 HomoloGene: 49934 GeneCards: SPZ1
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za SPZ1
Genomska lokacija za SPZ1
Bend5q14.1Početak80,319,625 bp[1]
Kraj80,321,842 bp[1]
Lokacija gena (miš)
Hromosom 13 (miš)
Hrom.Hromosom 13 (miš)[2]
Hromosom 13 (miš)
Genomska lokacija za SPZ1
Genomska lokacija za SPZ1
Bend13|13 C3Početak92,711,144 bp[2]
Kraj92,712,680 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje sa DNK
GO:0001948, GO:0016582 vezivanje za proteine
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
Ćelijska komponenta citoplazma
jedro
Biološki proces transcription, DNA-templated
GO:0009373 regulation of transcription, DNA-templated
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_032567

NM_030237

RefSeq (bjelančevina)

NP_115956

NP_084513

Lokacija (UCSC)Chr 5: 80.32 – 80.32 MbChr 13: 92.71 – 92.71 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 430 aminokiselina, а molekulska težina 49.445 Da.[11]

1020304050
MASSAKSAEMPTISKTVNPTPDPHQEYLDPRITIALFEIGSHSPSSWGSL
PFLKNSSHQVTEQQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELFEET
NITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQEMILETNI
TEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQQMIMENQNSE
NTAQVFARDLVNRLEEKKVLNETQQSQEKAKNRLNVQEETMKIRNNMEQL
LQEAEHWSKQHTELSKLIKSYQKSQKDISETLGNNGVGFQTQPNNEVSAK
HELEEQVKKLSHDTYSLQLMAALLENECQILQQRVEILKELHHQKQGTLQ
EKPIQINYKQDKKNQKPSEAKKVEMYKQNKQAMKGTFWKKDRSCRSLDVC
LNKKACNTQFNIHVARKALRGKMRSASSLR

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164299 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046957 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev. 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID 11165476. S2CID 17206805.
  6. ^ Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl. 5 (2): 83–8. PMID 12778315.
  7. ^ Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem. 279 (35): 37079–86. doi:10.1074/jbc.M403710200. PMID 15226296.
  8. ^ Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod. 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID 15829580.
  9. ^ Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (maj 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res. 65 (10): 4041–50. doi:10.1158/0008-5472.CAN-04-3658. PMID 15899793.
  10. ^ "Entrez Gene: SPZ1 spermatogenic leucine zipper 1".
  11. ^ "UniProt, Q9BXG8" (jezik: engleski). Pristupljeno 20. 10. 2021.

Dopunska literatura

uredi