SPA17

Spermnopovršinski protein Sp17 je protein koji je kod ljudi kodiran genom SPA17.

SPA17
Identifikatori
Aliasi	SPA17
Vanjski ID-jevi	OMIM: 608621 MGI: 1333778 HomoloGene: 7951 GeneCards: SPA17
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11q24.2 Početak 124,673,844 bp Kraj 124,697,518 bp
Lokacija gena (miš) Hrom. Hromosom 9 (miš) Bend 9|9 A4 Početak 37,514,586 bp Kraj 37,525,018 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • calmodulin binding Ćelijska komponenta • citoplazma • sperm principal piece • motile cilium • sperm fibrous sheath • external side of plasma membrane • membrana • Treplja • extracellular region Biološki proces • epithelial cilium movement involved in extracellular fluid movement • Spermatogeneza • single fertilization • binding of sperm to zona pellucida Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	53340	20686
Ensembl	ENSG00000064199	ENSMUSG00000001948
UniProt	Q15506	Q62252
RefSeq (mRNK)	NM_017425	NM_011449 NM_001324545
RefSeq (bjelančevina)	NP_059121	NP_001311474 NP_035579
Lokacija (UCSC)	Chr 11: 124.67 – 124.7 Mb	Chr 9: 37.51 – 37.53 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira protein na površini ćelije. Studije na kunićima ukazuju na to da je u spermni protein uključen u oplodnju, vezanjem za zona pellucida oocita. Druge studije na kunićima ukazuju na to da je također uključen u dodatne adhezijske funkcije ćelija-ćelija kao što su migracija imunskih ćelija i metastaze.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 151 aminokiselina, а molekulska težina 17.406 Da.

10		20		30		40		50
MSIPFSNTHY		RIPQGFGNLL		EGLTREILRE		QPDNIPAFAA		AYFESLLEKR
EKTNFDPAEW		GSKVEDRFYN		NHAFEEQEPP		EKSDPKQEES		QISGKEEETS
VTILDSSEED		KEKEEVAAVK		IQAAFRGHIA		REEAKKMKTN		SLQNEEKEEN
K

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Dopunska literatura

• McLeskey SB, Dowds C, Carballada R, et al. (1997). Molecules involved in mammalian sperm-egg interaction. Int. Rev. Cytol. International Review of Cytology. 177. str. 57–113. doi:10.1016/S0074-7696(08)62231-7. ISBN 9780123645814. PMID 9378618.
• Richardson RT, Yamasaki N, O'Rand MG (1994). "Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction". Dev. Biol. 165 (2): 688–701. doi:10.1006/dbio.1994.1285. PMID 7525387.
• Kong M, Richardson RT, Widgren EE, O'Rand MG (1995). "Sequence and localization of the mouse sperm autoantigenic protein, Sp17". Biol. Reprod. 53 (3): 579–90. doi:10.1095/biolreprod53.3.579. PMID 7578682.
• Fujita A, Nakamura K, Kato T, et al. (2000). "Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella". J. Cell Sci. 113 (1): 103–12. PMID 10591629.
• Wen Y, Richardson RT, Widgren EE, O'Rand MG (2001). "Characterization of Sp17: a ubiquitous three domain protein that binds heparin". Biochem. J. 357 (Pt 1): 25–31. doi:10.1042/0264-6021:3570025. PMC 1221924. PMID 11415432.
• De Jong A, Buchli R, Robbins D (2003). "Characterization of sperm protein 17 in human somatic and neoplastic tissue". Cancer Lett. 186 (2): 201–9. doi:10.1016/S0304-3835(02)00350-6. PMID 12213290.
• Buchli R, De Jong A, Robbins DL (2002). "Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model". Biochim. Biophys. Acta. 1578 (1–3): 29–42. doi:10.1016/S0167-4781(02)00478-5. PMID 12393185.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Frayne J, Hall L (2003). "A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding". Reproduction. 124 (6): 767–74. doi:10.1530/rep.0.1240767. PMID 12530914.
• Takeoka Y, Kenny TP, Yago H, et al. (2004). "Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes". Dev. Immunol. 9 (2): 97–102. doi:10.1080/1044667021000095186. PMC 2276097. PMID 12739786.
• Chiriva-Internati M, Wang Z, Pochopien S, et al. (2004). "Identification of a sperm protein 17 CTL epitope restricted by HLA-A1". Int. J. Cancer. 107 (5): 863–5. doi:10.1002/ijc.11486. PMID 14566839. S2CID 30452400.
• Straughn JM, Shaw DR, Guerrero A, et al. (2004). "Expression of sperm protein 17 (Sp17) in ovarian cancer". Int. J. Cancer. 108 (6): 805–11. doi:10.1002/ijc.11617. PMID 14712480. S2CID 20294805.
• Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. Biol. Endocrinol. 2: 57. doi:10.1186/1477-7827-2-57. PMC 484205. PMID 15257753.
• Wang Z, Zhang Y, Ramsahoye B, et al. (2004). "Sp17 gene expression in myeloma cells is regulated by promoter methylation". Br. J. Cancer. 91 (8): 1597–603. doi:10.1038/sj.bjc.6602160. PMC 2409933. PMID 15381930.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gupta G, Sharma R, Chattopadhyay TK, et al. (2007). "Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer". Int. J. Cancer. 120 (8): 1739–47. doi:10.1002/ijc.22463. PMID 17230514. S2CID 31927317.