SP140

Protein jedarnog tijela SP14 jest protein koji je kod ljudi kodiran genom SP140 sa hromosoma 2.

SP140
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 2MD7, 2MD8
Identifikatori
Aliasi	SP140
Vanjski ID-jevi	OMIM: 608602 MGI: 3702467 HomoloGene: 128391 GeneCards: SP140
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek) Bend 2q37.1 Početak 230,203,110 bp Kraj 230,313,215 bp
Lokacija gena (miš) Hrom. Hromosom 1 (miš) Bend 1|1 C5 Početak 85,600,378 bp Kraj 85,645,037 bp
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala Ćelijska komponenta • citoplazma • PML body • nuclear envelope • mitohondrija • jedro • nukleoplazma • fibrillar center • nuclear body Biološki proces • defense response • GO:0009373 regulation of transcription, DNA-templated Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	11262	434484
Ensembl	ENSG00000079263	ENSMUSG00000070031
UniProt	Q13342	n/a
RefSeq (mRNK)	NM_001005176 NM_001278451 NM_001278452 NM_001278453 NM_007237	NM_001013817
RefSeq (bjelančevina)	NP_001005176 NP_001265380 NP_001265381 NP_001265382 NP_009168	n/a
Lokacija (UCSC)	Chr 2: 230.2 – 230.31 Mb	Chr 1: 85.6 – 85.65 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 867 aminokiselina, a molekulska težina 98.223 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAQQGQQGQM		ASGDSNLNFR		MVAEIQNVEG		QNLQEQVCPE		PIFRFFRENK
VEIASAITRP		FPFLMGLRDR		SFISEQMYEH		FQEAFRNLVP		VTRVMYCVLS
ELEKTFGWSH		LEALFSRINL		MAYPDLNEIY		RSFQNVCYEH		SPLQMNNVND
LEDRPRLLPY		GKQENSNACH		EMDDIAVPQE		ALSSSPRCEP		GFSSESCEQL
ALPKAGGGDA		EDAPSLLPGG		GVSCKLAIQI		DEGESEEMPK		LLPYDTEVLE
SNGMIDAART		YSTAPGEKQG		EEEGRNSPRK		RNQDKEKYQE		SPEGRDKETF
DLKTPQVTNE		GEPEKGLCLL		PGEGEEGSDD		CSEMCDGEEP		QEASSSLARC
GSVSCLSAET		FDLKTPQVTN		EGEPEKELSL		LPGEGEEGSD		DCSEMCDGEE
RQEASSSLAR		RGSVSSELEN		HPMNEEGESE		ELASSLLYDN		VPGAEQSAYE
NEKCSCVMCF		SEEVPGSPEA		RTESDQACGT		MDTVDIANNS		TLGKPKRKRR
KKRGHGWSRM		RMRRQENSQQ		NDNSKADGQV		VSSEKKANVN		LKDLSKIRGR
KRGKPGTRFT		QSDRAAQKRV		RSRASRKHKD		ETVDFKAPLL		PVTCGGVKGI
LHKKKLQQGI		LVKCIQTEDG		KWFTPTEFEI		KGGHARSKNW		RLSVRCGGWP
LRWLMENGFL		PDPPRIRYRK		KKRILKSQNN		SSVDPCMRNL		DECEVCRDGG
ELFCCDTCSR		VFHEDCHIPP		VEAERTPWNC		IFCRMKESPG		SQQCCQESEV
LERQMCPEEQ		LKCEFLLLKV		YCCSESSFFA		KIPYYYYIRE		ACQGLKEPMW
LDKIKKRLNE		HGYPQVEGFV		QDMRLIFQNH		RASYKYKDFG		QMGFRLEAEF
EKNFKEVFAI		QETNGNN

Dopunska literatura

• Madani N, Millette R, Platt EJ, Marin M, Kozak SL, Bloch DB, Kabat D (2002). "Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1". J. Virol. 76 (21): 11133–8. doi:10.1128/jvi.76.21.11133-11138.2002. PMC 136615. PMID 12368356.

Vanjski linkovi

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear body protein SP140